Cellular and molecular neuroscience of alcoholism

被引：289

作者：

Diamond, I

Gordon, AS

机构：

[1] UNIV CALIF SAN FRANCISCO, SAN FRANCISCO GEN HOSP, NEUROSCI PROGRAM, SAN FRANCISCO, CA 94110 USA

[2] UNIV CALIF SAN FRANCISCO, SAN FRANCISCO GEN HOSP, DEPT MOL & CELLULAR PHARMACOL, SAN FRANCISCO, CA 94110 USA

来源：

PHYSIOLOGICAL REVIEWS | 1997年 / 77卷 / 01期

关键词：

D O I：

10.1152/physrev.1997.77.1.1

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Recent advances in neuroscience have made it possible to investigate the pathophysiology of alcoholism at a cellular and molecular level. Evidence indicates that ethanol affects hormone- and neurotransmitter-activated signal transduction, leading to short-term changes in regulation of cellular functions and long-term changes in gene expression. Such changes in the brain probably underlie many of the acute and chronic neurological events in alcoholism. In addition, genetic vulnerability also plays a role in alcoholism and, perhaps, in alcoholic medical disorders.

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页码：1 / 20

页数：20

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