Prolactin Mediated Intracellular Signaling in Mammary Epithelial Cells

被引：36

作者：

Hynes, Nancy E. ^{[1
]}

Cella, Nathalie ^{[1
]}

Wartmann, Markus ^{[2
]}

机构：

[1] Friedrich Miescher Inst, CH-4002 Basel, Switzerland

[2] Ciba Geigy Ltd, CH-4002 Basel, Switzerland

来源：

JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA | 1997年 / 2卷 / 01期

关键词：

beta-casein gene transcription; JAK; Stat; MAP kinase; She; SHP-2;

D O I：

10.1023/A:1026317428542

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Prolactin binds to a member of the cytokine receptor superfamily. The cytoplasmic domain of the prolactin receptor (PrlR)(4) displays no enzymatic activity yet prolactin treatment leads to the induction of protein tyrosine phosphorylation. PrlR is associated with JAK2, a protein tyrosine kinase whose activity is stimulated following receptor dimerization. JAK2 subsequently phosphorylates PrlR and other cellular proteins which are recruited to the activated receptor complex. Among the JAK2 substrates is the transcription factor Stat5 whose phosphorylation mediates the transcriptional activation of beta-casein gene expression. In this review we discuss the prolactin induced signaling pathways which mediate differentiation of the mammary gland.

引用

页码：19 / 27

页数：9

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