Pentraxins, humoral innate immunity and tissue injury

被引：113

作者：

Manfredi, Angelo A. ^{[3
,4
]}

Rovere-Querini, Patrizia ^{[3
,4
]}

Bottazzi, Barbara ^{[1
]}

Garlanda, Cecilia ^{[1
]}

Mantovani, Alberto ^{[1
,2
]}

机构：

[1] Ist Clin Humanitas, I-20089 Milan, Italy

[2] Univ Milan, Inst Gen Pathol, Milan, Italy

[3] Univ Vita Salute San Raffaele, I-20132 Milan, Italy

[4] H San Raffaele Sci Inst, I-20132 Milan, Italy

来源：

CURRENT OPINION IN IMMUNOLOGY | 2008年 / 20卷 / 05期

关键词：

D O I：

10.1016/j.coi.2008.05.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Tissue damage elicits an inflammatory response, which comprises the rapid synthesis of acute phase molecules. The early local response shapes the resolution of inflammation. Pentraxins are evolutionary conserved soluble pattern recognition receptors, produced in the liver (e.g. C-reactive protein) or at sites of inflammation (the long pentraxin PTX3). Pentraxins behave as flexible adaptors of innate cell functions, complement activation and clearance of cell and matrix debris, regulating tissue hyperplasia and scarring and limiting the risk of autoimmunity associated to unscheduled cell death in vivo.

引用

页码：538 / 544

页数：7

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