Association between periodontal disease, tooth loss and liver diseases risk

被引:48
作者
Chen, You [1 ]
Yang, Yu-chong [2 ]
Zhu, Bao-ling [3 ,4 ]
Wu, Cong-cong [3 ,4 ]
Lin, Rui-fang [3 ,4 ]
Zhang, Xi [3 ,4 ]
机构
[1] Dalian Med Univ, Coll Stomatol, Dalian, Peoples R China
[2] Tianjin Med Univ, Natl Clin Res Ctr Canc, Tianjin Med Univ Canc Inst & Hosp, Tianjins Clin Res Ctr Canc,Key Lab Canc Prevent &, Tianjin, Peoples R China
[3] Wenzhou Med Univ, Affiliated Hosp 2, Dept Chemotherapy & Radiotherapy, 109 Xueyuan West Rd, Wenzhou 325027, Peoples R China
[4] Wenzhou Med Univ, Yuying Childrens Hosp, 109 Xueyuan West Rd, Wenzhou 325027, Peoples R China
关键词
cirrhosis; liver cancer; non-alcoholic fatty liver disease; periodontal disease; tooth loss; DOSE-RESPONSE DATA; CANCER; INFLAMMATION; METAANALYSIS; COHORT; STEATOHEPATITIS; EXTRACTION; REASONS;
D O I
10.1111/jcpe.13341
中图分类号
R78 [口腔科学];
学科分类号
100302 [口腔临床医学];
摘要
Aim The purpose of this study is to assess the associations between periodontal disease, tooth loss and liver diseases. Materials and methods PubMed and Embase databases were utilized to search eligible studies. Odds ratio (OR) with 95% confidence interval (CI) was used as effect size to assess the associations between periodontal disease, tooth loss and liver diseases risk. Results Our results indicated positive associations between periodontal disease and non-alcoholic fatty liver disease (NAFLD) (OR = 1.19, 95% CI = 1.06-1.33), liver cirrhosis (OR = 2.28, 95% CI = 1.50-3.48) and elevated transaminase level risk (OR = 1.08, 95% CI = 1.02-1.15). Moreover, tooth loss could increase NAFLD (OR = 1.33, 95% CI = 1.12- 1.56) and liver cancer risk (OR = 1.34, 95% CI = 1.04-1.74), and every five increment in tooth loss was associated with 5% increased liver cancer risk (OR = 1.05, 95% CI = 1.01 - 1.10) with a linear relationship. In addition, tooth loss had a positive tendency towards liver cirrhosis risk (OR = 2.03, 95% CI = 0.85-4.85) although there was no statistical significance. Conclusion Periodontal disease and tooth loss are positively associated with liver diseases including NAFLD, elevated transaminase level, liver cirrhosis and liver cancer.
引用
收藏
页码:1053 / 1063
页数:11
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