Regular alcohol consumption mimics cardiac preconditioning by protecting against ischemia-reperfusion injury

被引:88
作者
Miyamae, M
Diamond, I
Weiner, MW
Camacho, SA
Figueredo, VM
机构
[1] SAN FRANCISCO GEN HOSP,DIV CARDIOL,DEPT MED CARDIOL,SAN FRANCISCO,CA 94110
[2] SAN FRANCISCO GEN HOSP,DEPT NEUROL,SAN FRANCISCO,CA 94110
[3] SAN FRANCISCO GEN HOSP,DEPT CELLULAR & MOL PHARMACOL,SAN FRANCISCO,CA 94110
[4] SAN FRANCISCO GEN HOSP,ERNEST GALLO CLIN & RES CTR,SAN FRANCISCO,CA 94110
[5] DEPT VET AFFAIRS MED CTR,MAGNET RESONNANCE UNIT,SAN FRANCISCO,CA 94110
[6] UNIV CALIF SAN FRANCISCO,SAN FRANCISCO,CA 94110
关键词
ethanol; adenosine; heart; guinea pig; myocardial infarction;
D O I
10.1073/pnas.94.7.3235
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Epidemiologic studies indicate that longterm alcohol consumption decreases the incidence of coronary disease and may improve outcome after myocardial infarction, Attenuation of ischemia-reperfusion injury after myocardial infarction improves survival, This study investigates the possibility that alcohol consumption can improve survival after myocardial infarction by reducing ischemia-reperfusion injury, Hearts were isolated from guinea pigs after drinking ethanol for 3-12 weeks and subjected to global ischemia and reperfusion, Hearts from animals drinking ethanol showed improved functional recovery and decreased myocyte damage when compared with controls, Adenosine A(1) receptor blockade abolished the protection provided by ethanol consumption, These findings indicate that long-term alcohol consumption reduces myocardial ischemia-reperfusion injury and that adenosine A(1) receptors are required for this protective effect of ethanol, This cardioprotective effect of long-term alcohol consumption mimics preconditioning and may, in part, account for the beneficial effect of moderate drinking on cardiac health.
引用
收藏
页码:3235 / 3239
页数:5
相关论文
共 40 条
[1]   ADENOSINE RECEPTOR SPECIFICITY IN PRECONDITIONING OF ISOLATED RABBIT CARDIOMYOCYTES - EVIDENCE OF A(3) RECEPTOR INVOLVEMENT [J].
ARMSTRONG, S ;
GANOTE, CE .
CARDIOVASCULAR RESEARCH, 1994, 28 (07) :1049-1056
[2]   ADENOSINE-A(1) RECEPTORS, K(ATP) CHANNELS, AND ISCHEMIC PRECONDITIONING IN DOGS [J].
AUCHAMPACH, JA ;
GROSS, GJ .
AMERICAN JOURNAL OF PHYSIOLOGY, 1993, 264 (05) :H1327-H1336
[3]  
CANO C, 1992, J PHARMACOL EXP THER, V261, P660
[4]   EFFECTS OF ADENOSINE IN SIMULATED ISCHEMIA AND REPERFUSION IN GUINEA-PIG VENTRICULAR MYOCYTES [J].
CORDEIRO, JM ;
FERRIER, GR ;
HOWLETT, SE .
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 1995, 269 (01) :H121-H129
[5]   Cellular and molecular neuroscience of alcoholism [J].
Diamond, I ;
Gordon, AS .
PHYSIOLOGICAL REVIEWS, 1997, 77 (01) :1-20
[6]  
DIAMOND I, 1994, ROLE ADENOSINE MEDIA, P175
[7]   Ethanol causes translocation of cAMP-dependent protein kinase catalytic subunit to the nucleus [J].
Dohrman, DP ;
Diamond, I ;
Gordon, AS .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (19) :10217-10221
[8]  
Dufour M.C., 1996, ALCOHOL CLIN EXP RES, V20, P97
[9]   POSTISCHEMIC REPERFUSION INJURY IN THE ISOLATED RAT-HEART - EFFECT OF RUTHENIUM RED [J].
FIGUEREDO, VM ;
DRESDNER, KP ;
WOLNEY, AC ;
KELLER, AM .
CARDIOVASCULAR RESEARCH, 1991, 25 (04) :337-342
[10]   ADENOSINE ATTENUATES REPERFUSION INJURY FOLLOWING REGIONAL MYOCARDIAL-ISCHEMIA [J].
FORMAN, MB ;
VELASCO, CE ;
JACKSON, EK .
CARDIOVASCULAR RESEARCH, 1993, 27 (01) :9-17