Mechanochemical preparation of co-crystals

被引：391

作者：

Braga, Dario ^{[1
]}

Maini, Lucia ^{[1
]}

Grepioni, Fabrizia ^{[1
]}

机构：

[1] Dipartimento Chim G Ciamician, I-40126 Bologna, Italy

来源：

CHEMICAL SOCIETY REVIEWS | 2013年 / 42卷 / 18期

关键词：

ACTIVE PHARMACEUTICAL INGREDIENTS; POWDER DIFFRACTION DATA; SOLID-SOLID REACTIONS; COCRYSTAL FORMATION; PHYSICOCHEMICAL PROPERTIES; ORGANIC-REACTIONS; CARBOXYLIC-ACIDS; MOLECULAR RECOGNITION; INCLUSION COMPLEXES; STEPWISE MECHANISM;

D O I：

10.1039/c3cs60014a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The preparation of co-crystals via mechanochemistry combines the quest for clean and green processes with the investigation of multicomponent new materials, among the currently most fashionable systems in the crystal engineering field: the physico-chemical properties of the components add, merge or transform when co-crystals are formed, giving rise to potentially improved performance in "old" solid-state chemistry fields, as in the pharmaceutical industry field, where they represent a way to obtain new formulations and to improve the properties (solubility, thermal stability, compressibility, etc.) of both new and existing drugs.

引用

页码：7638 / 7648

页数：11

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