The search for IDDM susceptibility genes - The next generation

被引：78

作者：

Owerbach, D

Gabbay, KH

机构：

来源：

DIABETES | 1996年 / 45卷 / 05期

关键词：

D O I：

10.2337/diabetes.45.5.544

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Two human chromosomal regions, the HLA region on chromosome 6p21 and the insulin gene region on chromosome 11p15, have been investigated in detail for more than 10 years for the presence of IDDM susceptibility genes. Recent genome searches indicate the possible existence of many additional susceptibility genes in IDDM. The lengthy and protracted studies to prove the linkage and identity of the susceptibility genes in the HLA and insulin gene regions provide a perspective and background for understanding the complexities and time course for characterization of the putative additional IDDM susceptibility genes uncovered by genome searches.

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页码：544 / 551

页数：16

相关论文

共 79 条

[1] INSULIN GENE REGION-ENCODED SUSCEPTIBILITY TO TYPE-1 DIABETES IS NOT RESTRICTED TO HLA-DR4-POSITIVE INDIVIDUALS [J].

BAIN, SC ;

PRINS, JB ;

HEARNE, CM ;

RODRIGUES, NR ;

ROWE, BR ;

PRITCHARD, LE ;

RITCHIE, RJ ;

HALL, JRS ;

UNDLIEN, DE ;

RONNINGEN, KS ;

DUNGER, DB ;

BARNETT, AH ;

TODD, JA .

NATURE GENETICS, 1992, 2 (03) :212-215

[2]

BARBOSA J, 1979, TISSUE ANTIGENS, V14, P426

[3]

BELL GI, 1980, NATURE, V284, P26, DOI 10.1038/284026a0

[4] THE HIGHLY POLYMORPHIC REGION NEAR THE HUMAN INSULIN GENE IS COMPOSED OF SIMPLE TANDEMLY REPEATING SEQUENCES [J].

BELL, GI ;

SELBY, MJ ;

RUTTER, WJ .

NATURE, 1982, 295 (5844) :31-35

[5] A POLYMORPHIC LOCUS NEAR THE HUMAN INSULIN GENE IS ASSOCIATED WITH INSULIN-DEPENDENT DIABETES-MELLITUS [J].

BELL, GI ;

HORITA, S ;

KARAM, JH .

DIABETES, 1984, 33 (02) :176-183

[6] ISOLATION OF THE HUMAN INSULIN-LIKE GROWTH-FACTOR GENES - INSULIN-LIKE GROWTH FACTOR-II AND INSULIN GENES ARE CONTIGUOUS [J].

BELL, GI ;

GERHARD, DS ;

FONG, NM ;

SANCHEZPESCADOR, R ;

RALL, LB .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (19) :6450-6454

[7] POLYMORPHIC DNA REGION ADJACENT TO THE 5'-END OF THE HUMAN INSULIN GENE [J].

BELL, GI ;

KARAM, JH ;

RUTTER, WJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (09) :5759-5763

[8] SUSCEPTIBILITY TO HUMAN TYPE-1 DIABETES AT IDDM2 IS DETERMINED BY TANDEM REPEAT VARIATION AT THE INSULIN GENE MINISATELLITE LOCUS [J].

BENNETT, ST ;

LUCASSEN, AM ;

GOUGH, SCL ;

POWELL, EE ;

UNDLIEN, DE ;

PRITCHARD, LE ;

MERRIMAN, ME ;

KAWAGUCHI, Y ;

DRONSFIELD, MJ ;

POCIOT, F ;

NERUP, J ;

BOUZEKRI, N ;

CAMBONTHOMSEN, A ;

RONNINGEN, KS ;

BARNETT, AH ;

BAIN, SC ;

TODD, JA .

NATURE GENETICS, 1995, 9 (03) :284-292

[9] PREVENTION OF DIABETES IN NONOBESE DIABETIC MICE BY ANTI-I-A MONOCLONAL-ANTIBODIES - TRANSFER OF PROTECTION BY SPLENIC T-CELLS [J].

BOITARD, C ;

BENDELAC, A ;

RICHARD, MF ;

CARNAUD, C ;

BACH, JF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (24) :9719-9723

[10]

Buhler Jeremy, 1995, American Journal of Human Genetics, V57, pA171

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