Myeloid-derived suppressor cells as regulators of the immune system

被引：5425

作者：

Gabrilovich, Dmitry I. ^{[1
]}

Nagaraj, Srinivas

机构：

[1] Univ S Florida, H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2009年 / 9卷 / 03期

关键词：

COLONY-STIMULATING FACTOR; TUMOR-ASSOCIATED MACROPHAGES; NITRIC-OXIDE SYNTHASE; GROWTH-FACTOR-BETA; BONE-MARROW-CELLS; REACTIVE OXYGEN; DENDRITIC CELLS; T-CELLS; CANCER-PATIENTS; ANTITUMOR IMMUNITY;

D O I：

10.1038/nri2506

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells that expand during cancer, inflammation and infection, and that have a remarkable ability to suppress T-cell responses. These cells constitute a unique component of the immune system that regulates immune responses in healthy individuals and in the context of various diseases. In this Review, we discuss the origin, mechanisms of expansion and suppressive functions of MDSCs, as well as the potential to target these cells for therapeutic benefit.

引用

页码：162 / 174

页数：13

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