Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease and is an important cause of chronic disability. Numerous important advances have been made in our understanding of the aetiopathogenesis, pathology and clinical phenomenology of this disease, and these have underpinned advances in symptomatic treatment and the prospect that these might be extended into interventions that will slow progression. It is notable that the continuing characterisation of the downstream biochemical consequences of the genetic causes of PD serves only to reinforce this notion. Progress in the management of PD has continued, particularly in timing of drug initiation and the sequence and combinations in which drugs are used to improve long-term outcome and reduce drug-induced complications. Particular progress has been made in the field of neuroprotection, where novel therapies and clinical trial designs are being tested. This review will focus particularly upon this area.
机构:
Univ Basel Hosp, Basel Pharmacoepidemiol Unit, Div Clin Pharmacol & Toxicol, CH-4031 Basel, SwitzerlandUniv Basel Hosp, Basel Pharmacoepidemiol Unit, Div Clin Pharmacol & Toxicol, CH-4031 Basel, Switzerland
Becker, Claudia
Jick, Susan S.
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Boston Univ, Med Ctr, Boston Collaborat Drug Surveillance Program, Lexington, MA USAUniv Basel Hosp, Basel Pharmacoepidemiol Unit, Div Clin Pharmacol & Toxicol, CH-4031 Basel, Switzerland
Jick, Susan S.
Meier, Christoph R.
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Univ Basel Hosp, Basel Pharmacoepidemiol Unit, Div Clin Pharmacol & Toxicol, CH-4031 Basel, Switzerland
Boston Univ, Med Ctr, Boston Collaborat Drug Surveillance Program, Lexington, MA USAUniv Basel Hosp, Basel Pharmacoepidemiol Unit, Div Clin Pharmacol & Toxicol, CH-4031 Basel, Switzerland
机构:
Tel Aviv Univ, Sackler Sch Med, Tel Aviv Sourasky Med Ctr,Dept Neurol, Tel Aviv Parkinson Ctr,Movement Disorders Unit, IL-64239 Tel Aviv, IsraelTel Aviv Univ, Sackler Sch Med, Tel Aviv Sourasky Med Ctr,Dept Neurol, Tel Aviv Parkinson Ctr,Movement Disorders Unit, IL-64239 Tel Aviv, Israel
Giladi, Nir
Boroojerdi, Babak
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SCHWARZ PHARMA AG, Monheim, GermanyTel Aviv Univ, Sackler Sch Med, Tel Aviv Sourasky Med Ctr,Dept Neurol, Tel Aviv Parkinson Ctr,Movement Disorders Unit, IL-64239 Tel Aviv, Israel
Boroojerdi, Babak
Korczyn, Amos D.
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Tel Aviv Univ, Sackler Sch Med, Chair Neurol, IL-64239 Tel Aviv, IsraelTel Aviv Univ, Sackler Sch Med, Tel Aviv Sourasky Med Ctr,Dept Neurol, Tel Aviv Parkinson Ctr,Movement Disorders Unit, IL-64239 Tel Aviv, Israel
Korczyn, Amos D.
Burn, David J.
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Univ Birmingham, Birmingham B15 2TT, W Midlands, England
City Hosp Birmingham, Dept Neurol, Birmingham, W Midlands, EnglandTel Aviv Univ, Sackler Sch Med, Tel Aviv Sourasky Med Ctr,Dept Neurol, Tel Aviv Parkinson Ctr,Movement Disorders Unit, IL-64239 Tel Aviv, Israel
Burn, David J.
Clarke, Carl E.
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City Hosp NHS Trust, Dept Neurol, Birmingham, W Midlands, EnglandTel Aviv Univ, Sackler Sch Med, Tel Aviv Sourasky Med Ctr,Dept Neurol, Tel Aviv Parkinson Ctr,Movement Disorders Unit, IL-64239 Tel Aviv, Israel
Clarke, Carl E.
Schapira, Anthony Hn.
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Inst Neurol, Dept Clin Neurosci, London WC1N 3BG, EnglandTel Aviv Univ, Sackler Sch Med, Tel Aviv Sourasky Med Ctr,Dept Neurol, Tel Aviv Parkinson Ctr,Movement Disorders Unit, IL-64239 Tel Aviv, Israel
机构:
Univ Basel Hosp, Basel Pharmacoepidemiol Unit, Div Clin Pharmacol & Toxicol, CH-4031 Basel, SwitzerlandUniv Basel Hosp, Basel Pharmacoepidemiol Unit, Div Clin Pharmacol & Toxicol, CH-4031 Basel, Switzerland
Becker, Claudia
Jick, Susan S.
论文数: 0引用数: 0
h-index: 0
机构:
Boston Univ, Med Ctr, Boston Collaborat Drug Surveillance Program, Lexington, MA USAUniv Basel Hosp, Basel Pharmacoepidemiol Unit, Div Clin Pharmacol & Toxicol, CH-4031 Basel, Switzerland
Jick, Susan S.
Meier, Christoph R.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Basel Hosp, Basel Pharmacoepidemiol Unit, Div Clin Pharmacol & Toxicol, CH-4031 Basel, Switzerland
Boston Univ, Med Ctr, Boston Collaborat Drug Surveillance Program, Lexington, MA USAUniv Basel Hosp, Basel Pharmacoepidemiol Unit, Div Clin Pharmacol & Toxicol, CH-4031 Basel, Switzerland
机构:
Tel Aviv Univ, Sackler Sch Med, Tel Aviv Sourasky Med Ctr,Dept Neurol, Tel Aviv Parkinson Ctr,Movement Disorders Unit, IL-64239 Tel Aviv, IsraelTel Aviv Univ, Sackler Sch Med, Tel Aviv Sourasky Med Ctr,Dept Neurol, Tel Aviv Parkinson Ctr,Movement Disorders Unit, IL-64239 Tel Aviv, Israel
Giladi, Nir
Boroojerdi, Babak
论文数: 0引用数: 0
h-index: 0
机构:
SCHWARZ PHARMA AG, Monheim, GermanyTel Aviv Univ, Sackler Sch Med, Tel Aviv Sourasky Med Ctr,Dept Neurol, Tel Aviv Parkinson Ctr,Movement Disorders Unit, IL-64239 Tel Aviv, Israel
Boroojerdi, Babak
Korczyn, Amos D.
论文数: 0引用数: 0
h-index: 0
机构:
Tel Aviv Univ, Sackler Sch Med, Chair Neurol, IL-64239 Tel Aviv, IsraelTel Aviv Univ, Sackler Sch Med, Tel Aviv Sourasky Med Ctr,Dept Neurol, Tel Aviv Parkinson Ctr,Movement Disorders Unit, IL-64239 Tel Aviv, Israel
Korczyn, Amos D.
Burn, David J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Birmingham, Birmingham B15 2TT, W Midlands, England
City Hosp Birmingham, Dept Neurol, Birmingham, W Midlands, EnglandTel Aviv Univ, Sackler Sch Med, Tel Aviv Sourasky Med Ctr,Dept Neurol, Tel Aviv Parkinson Ctr,Movement Disorders Unit, IL-64239 Tel Aviv, Israel
Burn, David J.
Clarke, Carl E.
论文数: 0引用数: 0
h-index: 0
机构:
City Hosp NHS Trust, Dept Neurol, Birmingham, W Midlands, EnglandTel Aviv Univ, Sackler Sch Med, Tel Aviv Sourasky Med Ctr,Dept Neurol, Tel Aviv Parkinson Ctr,Movement Disorders Unit, IL-64239 Tel Aviv, Israel
Clarke, Carl E.
Schapira, Anthony Hn.
论文数: 0引用数: 0
h-index: 0
机构:
Inst Neurol, Dept Clin Neurosci, London WC1N 3BG, EnglandTel Aviv Univ, Sackler Sch Med, Tel Aviv Sourasky Med Ctr,Dept Neurol, Tel Aviv Parkinson Ctr,Movement Disorders Unit, IL-64239 Tel Aviv, Israel