Neurobiology and treatment of Parkinson's disease

被引:164
作者
Schapira, Anthony H. V. [1 ,2 ]
机构
[1] UCL, Inst Neurol, Univ Dept Clin Neurosci, London NW3 2PF, England
[2] UCL, Inst Neurol, London WC1N 3BG, England
关键词
COMPLEX-I DEFICIENCY; ALPHA-SYNUCLEIN; DOUBLE-BLIND; MOTOR FLUCTUATIONS; NONMOTOR SYMPTOMS; PINK1; MUTATIONS; GENE; LEVODOPA; PROGRESSION; FAMILIES;
D O I
10.1016/j.tips.2008.10.005
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease and is an important cause of chronic disability. Numerous important advances have been made in our understanding of the aetiopathogenesis, pathology and clinical phenomenology of this disease, and these have underpinned advances in symptomatic treatment and the prospect that these might be extended into interventions that will slow progression. It is notable that the continuing characterisation of the downstream biochemical consequences of the genetic causes of PD serves only to reinforce this notion. Progress in the management of PD has continued, particularly in timing of drug initiation and the sequence and combinations in which drugs are used to improve long-term outcome and reduce drug-induced complications. Particular progress has been made in the field of neuroprotection, where novel therapies and clinical trial designs are being tested. This review will focus particularly upon this area.
引用
收藏
页码:41 / 47
页数:7
相关论文
共 84 条
  • [1] A wide variety of mutations in the parkin gene are responsible for autosomal recessive parkinsonism in Europe
    Abbas, N
    Lücking, CB
    Ricard, S
    Dürr, A
    Bonifati, V
    De Michele, G
    Bouley, S
    Vaughan, JR
    Gasser, T
    Marconi, R
    Broussolle, E
    Brefel-Courbon, C
    Harhangi, BS
    Oostra, AB
    Fabrizio, E
    Böhme, GA
    Pradier, L
    Wood, NW
    Filla, A
    Meco, G
    Denefle, P
    Agid, Y
    Brice, A
    [J]. HUMAN MOLECULAR GENETICS, 1999, 8 (04) : 567 - 574
  • [2] Use of antihypertensives and the risk of Parkinson disease
    Becker, Claudia
    Jick, Susan S.
    Meier, Christoph R.
    [J]. NEUROLOGY, 2008, 70 (16) : 1438 - 1444
  • [3] Creatine supplementation in Parkinson disease:: A placebo-controlled randomized pilot trial
    Bender, A.
    Koch, W.
    Elstner, M.
    Schombacher, Y.
    Bender, J.
    Moeschl, M.
    Gekeler, F.
    Mueller-Myhsok, B.
    Gasser, T.
    Tatsch, K.
    Klopstock, T.
    [J]. NEUROLOGY, 2006, 67 (07) : 1262 - 1264
  • [4] Staging of brain pathology related to sporadic Parkinson's disease
    Braak, H
    Del Tredici, K
    Rüb, U
    de Vos, RAI
    Steur, ENHJ
    Braak, E
    [J]. NEUROBIOLOGY OF AGING, 2003, 24 (02) : 197 - 211
  • [5] 'Rejuvenation' protects neurons in mouse models of Parkinson's disease
    Chan, C. Savio
    Guzman, Jaime N.
    Ilijic, Ema
    Mercer, Jeff N.
    Rick, Caroline
    Tkatch, Tatiana
    Meredith, Gloria E.
    Surmeier, D. James
    [J]. NATURE, 2007, 447 (7148) : 1081 - U5
  • [6] Non-motor symptoms of Parkinson's disease: diagnosis and management
    Chaudhuri, KR
    Healy, DG
    Schapira, AHV
    [J]. LANCET NEUROLOGY, 2006, 5 (03) : 235 - 245
  • [7] Fahn S, 2004, NEW ENGL J MED, V351, P2498
  • [8] Comparison of kindreds with parkinsonism and α-synuclein genomic multiplications
    Farrer, M
    Kachergus, J
    Forno, L
    Lincoln, S
    Wang, DS
    Hulihan, M
    Maraganore, D
    Gwinn-Hardy, K
    Wszolek, Z
    Dickson, D
    Langston, JW
    [J]. ANNALS OF NEUROLOGY, 2004, 55 (02) : 174 - 179
  • [9] Transplantation of embryonic dopamine neurons for severe Parkinson's disease.
    Freed, CR
    Greene, PE
    Breeze, RE
    Tsai, WY
    DuMouchel, W
    Kao, R
    Dillon, S
    Winfield, H
    Culver, S
    Trojanowski, JQ
    Eidelberg, D
    Fahn, S
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2001, 344 (10) : 710 - 719
  • [10] Rotigotine transdermal patch in early Parkinson's disease: A randomized, double-blind, controlled study versus placebo and ropinirole
    Giladi, Nir
    Boroojerdi, Babak
    Korczyn, Amos D.
    Burn, David J.
    Clarke, Carl E.
    Schapira, Anthony Hn.
    [J]. MOVEMENT DISORDERS, 2007, 22 (16) : 2398 - 2404