Cdc7 expression in melanomas, Spitz tumors and melanocytic nevi

被引:24
作者
Clarke, Loren E. [1 ,2 ]
Fountaine, Thomas J. [1 ]
Hennessy, Jeannie [1 ]
Bruggeman, Richard D. [1 ]
Clarke, Jennie T. [2 ]
Mauger, David T. [3 ]
Helm, Klaus F. [1 ,2 ]
机构
[1] Penn State Milton S Hershey Med Ctr Coll Med, Dept Pathol, Hershey, PA 17033 USA
[2] Penn State Milton S Hershey Med Ctr Coll Med, Dept Dermatol, Hershey, PA 17033 USA
[3] Penn State Milton S Hershey Med Ctr Coll Med, Dept Hlth Evaluat Sci, Hershey, PA 17033 USA
关键词
CUTANEOUS MALIGNANT-MELANOMA; CELL-CYCLE; KINASE COMPLEX; PROGNOSIS; GENE; REPLICATION; MIB-1;
D O I
10.1111/j.1600-0560.2008.01077.x
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Cdc7 is a serine-threonine kinase required for initiation of DNA replication that may play a role in the development and progression of melanoma. Tissue microarrays containing 40 melanomas, 40 Spitz tumors and 30 nevi were constructed. Staining for Cdc7 was scored semiquantitatively according to intensity and extent, and the values were converted into composite scores. Nodular melanomas, atypical Spitz tumors and superficial spreading melanomas had the highest scores (nodular melanomas, 3.67; atypical Spitz tumors, 2.78 and superficial spreading melanomas, 2.44). Typical Spitz nevi, dysplastic nevi and ordinary nevi had the lowest scores. Cdc7 expression in melanomas differed significantly from non-Spitz nevi (p < 0.001). The difference was also significant when invasive melanomas were compared with dysplastic nevi (p < 0.005) and when invasive melanomas were compared with non-atypical Spitz nevi (p < 0.001). However, there was no significant difference between invasive melanomas and atypical Spitz tumors (p = 0.69) or between dysplastic nevi and ordinary nevi (p = 0.73). Cdc7 expression differs significantly among cutaneous melanocytic neoplasms and can be evaluated by routine immunohistochemical methods. The results suggest that differences in Cdc7 expression may account for some of the differences between malignant melanomas and benign melanocytic nevi. Clarke LE, Fountaine TJ, Hennessy J, Bruggeman RD, Clarke JT, Mauger DT, Helm KF. Cdc7 expression in melanomas, Spitz tumors and melanocytic nevi.J Cutan Pathol 2009; 36: 433-438. (C) 2008 Blackwell Munksgaard.
引用
收藏
页码:433 / 438
页数:6
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