B7-CTLA4 interaction promotes cognate destruction of tumor cells by cytotoxic T lymphocytes in vivo

被引:18
作者
Bai, XF
Liu, JQ
May, KF
Guo, Y
Zheng, P
Liu, Y
机构
[1] Ohio State Univ, Med Ctr, Dept Pathol, Columbus, OH 43210 USA
[2] Ohio State Univ, Med Ctr, Ctr Comprehens Canc, Columbus, OH 43210 USA
关键词
D O I
10.1182/blood.V99.8.2880
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Costimulatory molecules B7-1 and B7-2 (hereby collectively called B7) interact with CD28 and CTLA4 on T cells and promote antitumor immunity. The function of B7-CTLA4 interaction in antitumor CTL response remains controversial. Here we used CD28(-/-) and CD28(+/-) or CD28(+/+) transgenic mice that express the T-cell receptor specific for an unmutated tumor antigen, PIA, and for tumor cells expressing a CTLA4-specific B7 mutant to evaluate the function of CD28-B7 and CTLA4-B7 interactions in induction and effector phases of antitumor immunity. We report that B7-CD28 and B7-CTLA4 interactions promote tumor rejection. However, this is achieved by distinct mechanisms. B7-CD28 interaction enhances T-cell clonal expansion, though a role for this interaction in the effector phase cannot be ruled out. In contrast, B7-CTLA4 interaction enhances the CTL-mediated destruction of tumors, but not T-cell clonal expansion, (C) 2002 by The American Society of Hematology.
引用
收藏
页码:2880 / 2889
页数:10
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