Low-barrier hydrogen bond between phosphate and the amide group in phosphopeptide

被引：47

作者：

Du, JT

Li, YM ^{[1
]}

Wei, W

Wu, GS

Zhao, YF

Kanazawa, K

Nemoto, T

Nakanishi, H

机构：

[1] Tsinghua Univ, Dept Chem, Minist Educ, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Beijing 100084, Peoples R China

[2] Natl Inst Adv Ind Sci & Technol, Biol Informat Res Ctr, Tsukuba, Ibaraki 3058566, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2005年 / 127卷 / 47期

关键词：

D O I：

10.1021/ja054568p

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

As the conversion between the monoionic (1) and diionic (2) form of the phosphate occurs, the phosphorylated peptides or proteins can not only cause the formation of a hydrogen bond between the phosphate group and the amide group but also change the strength of the hydrogen bond to form low-barrier hydrogen bonds (LBHBs). This reversible protonation of the phosphate group, which changes both the electrostatic properties of the phosphate group and the strength of the hydrogen bond, provides a possible mechanism in regulating protein function. Copyright © 2005 American Chemical Society.

引用

页码：16350 / 16351

页数：2

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