Upregulation of hypoxia-induced mitogenic factor in bacterial lipopolysaccharide-induced acute lung injury

被引：35

作者：

Tong, QS

Zheng, LD

Kang, QH

Dodd-o, J

Langer, J

Li, B

Wang, DM

Li, DC

机构：

[1] St Louis Univ, Sch Med, Dept Internal Med, Div Pulm Crit Care & Sleep Med, St Louis, MO 63110 USA

[2] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Pathol, Wuhan 430022, Hubei, Peoples R China

[3] Johns Hopkins Univ, Dept Anesthesiol, Baltimore, MD 21287 USA

[4] Johns Hopkins Univ, CCM, Baltimore, MD 21287 USA

来源：

FEBS LETTERS | 2006年 / 580卷 / 09期

关键词：

hypoxia-induced mitogenic factor; lipopolysaccharide; gene expression; acute lung injury;

D O I：

10.1016/j.febslet.2006.03.027

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Hypoxia-induced mitogenic factor (HIMF), also known as FIZZ1 (found in inflammatory zone), plays important roles in lung inflammation. We found that intraperitoneal injection of lipopolysaccharide (LPS) induced intensive HIMF production exclusively in mouse lung, but not: in the heart, liver, spleen or kidney. This HIMF production, at least partly, contributes to LPS-induced vascular cell adhesion molecule-1 (VCAM-1) upregulation and mononuclear cell sequestration to lung parenchyma, while protecting alveolar type 11 cells from LPS-resulted decrease in surfactant protein-C production and cell death. These data indicate that HIMF participates in LPS-induced acute lung injury and inflammation through modulating VCAM-1 and SP-C expression. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：2207 / 2215

页数：9

共 22 条

[1]

Effects of acute hypoxia and lipopolysaccharide on nitric oxide synthase-2 expression in acute lung injury [J].

Agorreta, J ;

Garayoa, M ;

Montuenga, LM ;

Zulueta, JJ .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2003, 168 (03) :287-296

[2]

THE AMERICAN-EUROPEAN CONSENSUS CONFERENCE ON ARDS - DEFINITIONS, MECHANISMS, RELEVANT OUTCOMES, AND CLINICAL-TRIAL COORDINATION [J].

BERNARD, GR ;

ARTIGAS, A ;

BRIGHAM, KL ;

CARLET, J ;

FALKE, K ;

HUDSON, L ;

LAMY, M ;

LEGALL, JR ;

MORRIS, A ;

SPRAGG, R ;

COCHIN, B ;

LANKEN, PN ;

LEEPER, KV ;

MARINI, J ;

MURRAY, JF ;

OPPENHEIMER, L ;

PESENTI, A ;

REID, L ;

RINALDO, J ;

VILLAR, J ;

VANASBECK, BS ;

DHAINAUT, JF ;

MANCEBO, J ;

MATTHAY, M ;

MEYRICK, B ;

PAYEN, D ;

PERRET, C ;

FOWLER, AA ;

SCHALLER, MD ;

HUDSON, LD ;

HYERS, T ;

KNAUS, W ;

MATTHAY, R ;

PINSKY, M ;

BONE, RC ;

BOSKEN, C ;

JOHANSON, WG ;

LEWANDOWSKI, K ;

REPINE, J ;

RODRIGUEZROISIN, R ;

ROUSSOS, C ;

ANTONELLI, MA ;

BELOUCIF, S ;

BIHARI, D ;

BURCHARDI, H ;

LEMAIRE, F ;

MONTRAVERS, P ;

PETTY, TL ;

ROBOTHAM, J ;

ZAPOL, W .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1994, 149 (03) :818-824

[3]

BRIGHAM KL, 1986, AM REV RESPIR DIS, V133, P913

[4]

TNF-α induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway [J].

Dumitru, CD ;

Ceci, JD ;

Tsatsanis, C ;

Kontoyiannis, D ;

Stamatakis, K ;

Lin, JH ;

Patriotis, C ;

Jenkins, NA ;

Copeland, NG ;

Kollias, G ;

Tsichlis, PN .

CELL, 2000, 103 (07) :1071-1083

[5]

VCAM-1 ON ACTIVATED ENDOTHELIUM INTERACTS WITH THE LEUKOCYTE INTEGRIN VLA-4 AT A SITE DISTINCT FROM THE VLA-4 FIBRONECTIN BINDING-SITE [J].

ELICES, MJ ;

OSBORN, L ;

TAKADA, Y ;

CROUSE, C ;

LUHOWSKYJ, S ;

HEMLER, ME ;

LOBB, RR .

CELL, 1990, 60 (04) :577-584

[6]

Hippenstiel S, 2000, BLOOD, V95, P3044

[7]

FIZZ1, a novel cysteine-rich secreted protein associated with pulmonary inflammation, defines a new gene family [J].

Holcomb, IN ;

Kabakoff, RC ;

Chan, B ;

Baker, TW ;

Gurney, A ;

Henzel, W ;

Nelson, C ;

Lowman, HB ;

Wright, BD ;

Skelton, NJ ;

Frantz, GD ;

Tumas, DB ;

Peale, FV ;

Shelton, DL ;

Hébert, CC .

EMBO JOURNAL, 2000, 19 (15) :4046-4055

[8]

Decreased surfactant protein-B expression and surfactant dysfunction in a marine model of acute lung injury [J].

Ingenito, EP ;

Mora, R ;

Cullivan, M ;

Marzan, Y ;

Haley, K ;

Mark, L ;

Sonna, LA .

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2001, 25 (01) :35-44

[9]

Transcriptional profiling of lipopolysaccharide-induced acute lung injury [J].

Jeyaseelan, S ;

Chu, HW ;

Young, SK ;

Worthen, GS .

INFECTION AND IMMUNITY, 2004, 72 (12) :7247-7256

[10]

Katzenstein A L, 1976, Am J Pathol, V85, P209

← 1 2 3 →