The emergence of clinical resistance to tigecycline

被引：215

作者：

Sun, Yan ^{[1
]}

Cai, Yun ^{[1
]}

Liu, Xu ^{[1
]}

Bai, Nan ^{[1
]}

Liang, Beibei ^{[1
]}

Wang, Rui ^{[1
]}

机构：

[1] Peoples Liberat Army Gen Hosp, Dept Clin Pharmacol, Beijing 100853, Peoples R China

来源：

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2013年 / 41卷 / 02期

基金：

北京市自然科学基金; 中国国家自然科学基金;

关键词：

Tigecycline; Multidrug resistance; Mechanism; IN-VITRO ACTIVITY; BACTEROIDES-FRAGILIS GROUP; MULTIDRUG EFFLUX PUMP; INTENSIVE-CARE-UNIT; ACINETOBACTER-BAUMANNII; ANTIMICROBIAL RESISTANCE; KLEBSIELLA-PNEUMONIAE; STENOTROPHOMONAS-MALTOPHILIA; DECREASED SUSCEPTIBILITY; STAPHYLOCOCCUS-AUREUS;

D O I：

10.1016/j.ijantimicag.2012.09.005

中图分类号：

R51 [传染病];

学科分类号：

100201 [内科学];

摘要：

Tigecycline (TIG) exhibits broad-spectrum activity against many Gram-positive and Gram-negative pathogens. However, clinical resistance has emerged recently and has been detected following treatment with TIG. This observation suggests that long-term monotherapy may carry a high risk for TIG resistance. TIG resistance is observed most frequently in Acinetobacter baumannii and Enterobacteriaceae, especially in multidrug-resistant strains. Resistance-nodulation-cell division (RND)-type transporters and other efflux pumps may be factors for decreased sensitivity to TIG. Therefore, TIG should be cautiously used in the clinic, and efflux-mediated resistance should be closely monitored in order to prolong the lifespan of this useful antibiotic. (C) 2012 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.

引用

页码：110 / 116

页数：7

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