Haptoglobin genotype and natural fertility in humans

被引:25
作者
Bottini, N
Gimelfarb, A
Gloria-Bottini, F
La Torre, M
Lucarelli, P
Lucarini, N
机构
[1] Univ Roma Tor Vergata, Cattedra Pediatria Preventiva & Sociale, Dipartimento Biopatol & Diagnost Immagini, I-00133 Rome, Italy
[2] Univ Camerino, I-62032 Camerino, Italy
[3] Univ Rome La Sapienza, Rome, Italy
[4] San Massimo Hosp, Penne, Italy
[5] Univ Maryland, College Pk, MD 20742 USA
关键词
haptoglobin; fertility; polymorphism; maternal age; fertility genetics;
D O I
10.1016/S0015-0282(99)00210-1
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: To study the possible relation between human natural fertility and haptoglobin (Hp) genotype. Design: Prospective study. Setting: Maternity departments of local hospitals in two Italian localities. Patient(s): Healthy women who had just given birth in the maternity departments of two local hospitals (n = 679). Intervention(s): Venous blood collection for determination of Hp genotype with the use of starch gel electrophoresis of hemoglobin-supplemented serum. Main Outcome Measure(s): Distribution of Hp genotypes in relation to age of puerperae. Result(s): In both populations, the proportion of young mothers was much higher among women who were homozygous for the Hp*1 allele (the Hp*1/*1 genotype) than among women who had other Hp genotypes. In addition, the proportion of multiparous women among the older mothers was higher among those with the Hp*1/*1 genotype than among those with other Hp genotypes. Conclusion(s): The data suggest that women with the Hp*1/*1 genotype reproduce at an earlier age and have higher natural fertility potential than women with other Hp genotypes. (C) 1999 by American Society for Reproductive Medicine.
引用
收藏
页码:293 / 296
页数:4
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