Proteome database of hepatocellular carcinoma

被引:43
作者
Liang, RCMY
Neo, JCH
Lo, SL
Tan, GS
Seow, TK
Chung, MCM [1 ]
机构
[1] Bioproc Technol Ctr, Singapore, Singapore
[2] Natl Univ Singapore, Fac Med, Dept Biochem, Singapore 119260, Singapore
来源
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES | 2002年 / 771卷 / 1-2期
关键词
reviews; proteomics; hepatocellular carcinoma;
D O I
10.1016/S1570-0232(02)00041-7
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Hepatocellular carcinoma (HCC or hepatoma) is the most common primary cancer of the liver. Persistent viral infection by the hepatic B or C virus is probably the most important cause of HCC worldwide. It is responsible for approximately one million deaths each year, predominantly in the underdeveloped and developing countries, but its incidence is also on the rise in the developed countries. For most patients suffering from HCC, long-term survival is rare, as they are presented late and are often unsuitable for curative treatment. Thus there is great interest to identify novel HCC diagnostic markers for early detection of the disease, and tumour specific associated proteins as potential therapeutic targets in the treatment of HCC. Proteome analyses of HCC cell lines and liver tumour tissues should facilitate the screening and discovery of these HCC proteins. The creation of a comprehensive HCC proteome database would be an important first step towards achieving this goal. This review presents an update of the two-dimensional electrophoresis proteome database of the cell line, HCC-M, which is also now freely accessible through the World Wide Web at http://proteome.btc.nus.edu.sg/hccm/. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:303 / 328
页数:26
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