Infection and cellular activation by human T-cell leukemia viruses, types I and II

被引:6
作者
Martin, TC [1 ]
Southern, PJ [1 ]
机构
[1] UNIV MINNESOTA,DEPT MICROBIOL,MINNEAPOLIS,MN 55455
关键词
D O I
10.1006/viro.1996.0389
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Resting peripheral blood mononuclear cells (PBMC) or purified T-cells can be induced to proliferate when cocultured in vitro with fixed HTLV-infected T-cells. This process of HTLV-dependent cellular activation and induction of proliferation has been considered distinctive because of an apparent independence from conventional T-cell costimulatory signals. We have examined several HTLV-infected cell lines and found that proliferation was readily induced in resting PBMC by T-cells that were productively-infected with HTLV. However, equivalent HTLV-productive infection in a B-cell line failed to induce proliferation in PBMC, suggesting that HTLV-dependent induction of proliferation in PBMC was, at least in part, dependent upon a T-cell-specific signal. Furthermore, the induction of proliferation in PBMC populations was found to overlap with, and actually require, transfer and establishment of HTLV infection within the T-cell compartment of the PBMC population. These findings suggest that virus-induced activation of target cells may be directly associated with transfer and spread of HTLV infection. (C) 1996 Academic Press, Inc.
引用
收藏
页码:375 / 381
页数:7
相关论文
共 32 条
[1]  
Cann AJ, 1996, FIELDS VIROLOGY, P1849
[2]   IDENTIFICATION OF DNA-REPLICATING LYMPHOCYTE SUBSETS USING A NEW METHOD TO LABEL THE BROMO-DEOXYURIDINE INCORPORATED INTO THE DNA [J].
CARAYON, P ;
BORD, A .
JOURNAL OF IMMUNOLOGICAL METHODS, 1992, 147 (02) :225-230
[3]   MOLECULAR CHARACTERIZATION OF GENOME OF A NOVEL HUMAN T-CELL LEUKEMIA-VIRUS [J].
CHEN, ISY ;
MCLAUGHLIN, J ;
GASSON, JC ;
CLARK, SC ;
GOLDE, DW .
NATURE, 1983, 305 (5934) :502-505
[4]   HUMAN T-CELL LEUKEMIA-VIRUS TYPE-II TRANSFORMS NORMAL HUMAN-LYMPHOCYTES [J].
CHEN, ISY ;
QUAN, SG ;
GOLDE, DW .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (22) :7006-7009
[5]   PRODUCTIVE INFECTION AND CELL-FREE TRANSMISSION OF HUMAN T-CELL LEUKEMIA-VIRUS IN A NON-LYMPHOID CELL-LINE [J].
CLAPHAM, P ;
NAGY, K ;
CHEINGSONGPOPOV, R ;
EXLEY, M ;
WEISS, RA .
SCIENCE, 1983, 222 (4628) :1125-1127
[6]   THE CD2 AND CD28 ADHESION MOLECULES INDUCE LONG-TERM AUTOCRINE PROLIFERATION OF CD4+ T-CELLS [J].
COSTELLO, R ;
CERDAN, C ;
PAVON, C ;
BRAILLY, H ;
HURPIN, C ;
MAWAS, C ;
OLIVE, D .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1993, 23 (03) :608-613
[7]   INFECTION WITH HUMAN T-LYMPHOTROPIC VIRUS TYPE-I AND TYPE-II RESULTS IN ALTERATIONS OF CELLULAR RECEPTORS, INCLUDING THE UP-MODULATION OF T-CELL COUNTERRECEPTORS CD40, CD54, AND CD80 (B7-1) [J].
DEZZUTTI, CS ;
RUDOLPH, DL ;
LAL, RB .
CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY, 1995, 2 (03) :349-355
[8]   PERIPHERAL T-LYMPHOCYTE ACTIVATION BY HUMAN T-CELL LEUKEMIA-VIRUS TYPE-I INTERFERES WITH THE CD2 BUT NOT WITH THE CD3 TCR PATHWAY [J].
DODON, MD ;
BERNARD, A ;
GAZZOLO, L .
JOURNAL OF VIROLOGY, 1989, 63 (12) :5413-5419
[9]   EFFECTS OF WHOLE-BLOOD LYSIS AND FIXATION ON THE INFECTIVITY OF HUMAN T-LYMPHOTROPIC VIRUS TYPE-1 (HTLV-I) [J].
ERICSON, JG ;
TREVINO, AV ;
TOEDTER, GP ;
MATHES, LE ;
NEWBOUND, GC ;
LAIRMORE, MD .
CYTOMETRY, 1994, 18 (01) :49-54
[10]  
GAZDAR AF, 1980, BLOOD, V55, P409