Mechanism of protection induced by vitamin A in falciparum malaria

被引:46
作者
Serghides, L
Kain, KC [1 ]
机构
[1] Toronto Gen Hosp, Dept Med, Div Infect Dis, Trop Dis Unit, Toronto, ON M5G 2C4, Canada
[2] Univ Toronto, Toronto, ON M5G 2C4, Canada
基金
加拿大健康研究院;
关键词
D O I
10.1016/S0140-6736(02)08360-5
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Supplementation with vitamin A potentiates host resistance to malaria, however, the underlying mechanism is unknown. We tested the effects of 9-cis-retinolc acid, a metabolite of vitamin A, on CD36 expression, non-opsonic phagocytic clearance of parasitised erythrocytes, and TNFalpha production in human monocytes and macrophages. We found reduced secretion of TNFalpha, upregulated CD36 expression, and increased phagocytosis of Plasmodium falciparum-parasitised erythrocytes. Increased parasite clearance and reduced proinflammatory cytokine responses to Infection might partly explain the beneficial effects of supplementation with vitamin A in malaria.
引用
收藏
页码:1404 / 1406
页数:3
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