Effect of the α2 adrenoreceptor antagonist, idazoxan, on motor disabilities in MPTP-treated monkey

被引:36
作者
Bezard, E [1 ]
Brefel, C
Tison, F
Peyro-Saint-Paul, H
Ladure, P
Rascol, O
Gross, CE
机构
[1] Univ Bordeaux 2, Basal Gang, Neurophysiol Lab, CNRS,UMR 5543, F-33076 Bordeaux, France
[2] CHU Toulouse, Serv Pharmacol Clin, INSERM, U455, Toulouse, France
[3] Inst Rech Pierre Fabre, Labege Innopole, France
关键词
alpha; 2; adrenoreceptor; idazoxan; L-dopa; monkey; MPTP; rigidity; Parkinson's disease;
D O I
10.1016/S0278-5846(99)00067-6
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
1. The motor effect of the alpha 2 adrenoreceptor antagonist, idazoxan, was compared to that of L-dopa in MPTP-treated monkeys. 2. Idazoxan 2.0 mg/kg improved parkinsonian motor abnormalities which was comparable to the effects of a minimal effective dose of L-dopa. 3. At 2.0 and 5.0 mg/kg, the parkinsonian rigidity was the item most frequently alleviated by idazoxan (respectively 63.6% and 68.2%). 4. These findings provide support for the therapeutic utility of alpha 2 antagonists in the treatment of Parkinson's disease.
引用
收藏
页码:1237 / 1246
页数:10
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