Corticotropin-releasing hormone-related peptides and receptors: Emergent regulators of cardiovascular adaptations to stress

被引：51

作者：

Coste, SC

Quintos, RF

Stenzel-Poore, MP

机构：

[1] Oregon Hlth & Sci Univ, Dept Mol Microbiol & Immunol, Portland, OR 97201 USA

[2] Oregon Hlth & Sci Ctr, Dept Mol Microbiol & Immunol, Portland, OR USA

[3] Oregon Hlth & Sci Ctr, Dept Med, Div Cardiol, Portland, OR USA

[4] Congenital Heart Res Ctr, Portland, OR USA

来源：

TRENDS IN CARDIOVASCULAR MEDICINE | 2002年 / 12卷 / 04期

关键词：

D O I：

10.1016/S1050-1738(02)00157-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Since its discovery 2 decades ago, potent effects of-corticotropin-releasing hormone (CRH) on the heart and vasculature have been consistently observed. The recent discoveries of novel CRH-related peptides residing in the heart and a distinct cardiac CRH receptor (CRH-R2), have renewed interest in the role of the CRH family on cardiovascular function. This review highlights the emerging view of a peripheral, cardiac CRH system and its potential relevance in mediating the adaptive response of the heart to stress. (C) 2002, Elsevier Science Inc.

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页码：176 / 182

页数：7

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