Influence of a total parenteral nutrition enriched with omega-3 fatty acids on leukotriene synthesis of peripheral leukocytes and systemic cytokine levels in patients with major surgery

被引:128
作者
Wachtler, P
Konig, W
Senkal, M
Kemen, M
Koller, M
机构
[1] RUHR UNIV BOCHUM, ST JOSEF HOSP, DEPT SURG, D-44780 BOCHUM, GERMANY
[2] RUHR UNIV BOCHUM, ST JOSEF HOSP, DEPT MICROBIOL & IMMUNOL, D-44780 BOCHUM, GERMANY
[3] RUHR UNIV BOCHUM, ST JOSEF HOSP, DEPT HOST DEF MECH, D-44780 BOCHUM, GERMANY
来源
JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE | 1997年 / 42卷 / 02期
关键词
total parenteral nutrition; eicosapentaenoic acid; leukotrienes; cytokines; omega-3 fatty acids; postoperative infection;
D O I
10.1097/00005373-199702000-00004
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Objective: Nutritive immunomodulation of patients after major surgery. Design: Prospective, randomized controlled double-blind study. Patients: Forty patients undergoing major intestinal surgery, Patients were divided into two groups: one received a total parenteral nutrition enriched with omega-3 fatty acids for 5 days postoperatively, the other an isocaloric, control nutrition. Material and Methods: We analyzed the leukocyte ability to release leukotrienes from whole blood leukocytes stimulated with the calcium ionophore A23187 (5 mu mol/L) by reverse phase high-performance liquid chromatography and circulating cytokines by enzyme-linked immunosorbent assay. Results: Leukocytes from patients of the omega-3 fatty acids group generated significantly higher amounts of less biologically active leukotriene B-5 as compared to the control group (p less than or equal to 0.001), This was accompanied by a significant decrease in the generation of proinflammatory leukotriene B-4 (p less than or equal to 0.006) in the study group. In contrast to interleukin-1 beta, interleukin-6, and interleukin-10 systemic levels of tumor necrosis factor-alpha (p less than or equal to 0.05) were postoperatively decreased in the study group. Conclusion: Our data provide evidence that a total parenteral nutrition enriched with omega-3 fatty acids modulates the lipid mediator pattern and systemic tumor necrosis factor-alpha levels.
引用
收藏
页码:191 / 198
页数:8
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