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The HER-2/neu oncogene:: prognostic factor, predictive factor and target for therapy

被引：156
作者：
Ross, JS
Fletcher, JA
机构：
[1] Albany Med Coll, Dept Pathol & Lab Med, Albany, NY 12208 USA
[2] Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA
[3] Harvard Univ, Sch Med, Boston, MA USA
来源：
SEMINARS IN CANCER BIOLOGY | 1999年 / 9卷 / 02期
关键词：
breast neoplasms; proto-oncogene; HER-2; neu prognosis; therapy;
D O I：
10.1006/scbi.1998.0083
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The HER-2/neu oncogene encodes a transmembrane tyrosine kinase receptor with extensive homology to the epidermal growth factor receptor HER-2/neu has been widely studied in breast cancer. The potential value of HER-2/neu status for the prediction of disease outcome and response to therapy in breast cancer is presented in the light of a series of recently Published studies showing a range of impact on thp outcome of patients treated with hormonal, cytotoxic and radiation therapies, This review includes the application of serum-based HER-2/neu testing and the use of antibody-based therapies directed against the HER-2/neu protein and their potential to become a new modality for breast cancer treatment.
引用
收藏
页码：125 / 138
页数：14
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