Orphanin FQ nociceptin blocks acquisition of morphine place preference

被引：136

作者：

Murphy, NP ^{[1
]}

Lee, Y ^{[1
]}

Maidment, NT ^{[1
]}

机构：

[1] Inst Neuropsychiat, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90024 USA

来源：

BRAIN RESEARCH | 1999年 / 832卷 / 1-2期

关键词：

orphanin FQ; nociceptin; opioid; morphine; reward; preference;

D O I：

10.1016/S0006-8993(99)01425-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Orphanin FQ/nociceptin (OFQ/N) suppresses the activity of the dopaminergic mesolimbic reward pathway yet reportedly fails to produce conditioned place aversion or preference. The present study sought to determine if this peptide could attenuate the development of morphine place preference. Male rats were administered OFQ/N (3 to 30 nmol intracerebroventricularly) during the induction of morphine (3 mg/kg subcutaneously) place preference. Animals receiving 3 or 10 nmol (but not 30 nmol) OFQ/N showed significant reductions in the development of place preference to morphine. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：168 / 170

页数：3

共 13 条

[1] Effect of nociceptin on alcohol intake in alcohol preferring rats [J].

Ciccocioppo, R ;

Panocka, I ;

Polidori, C ;

Regoli, D ;

Massi, M .

PSYCHOPHARMACOLOGY, 1999, 141 (02) :220-224

[2]

Devine DP, 1996, BRAIN RES, V727, P225

[3]

FUNADA M, 1993, NEUROPHARMACOLOGY, V32, P1315

[4]

IWAMOTO E T, 1986, Alcohol and Drug Research, V6, P327

[5] ANIMAL-MODELS OF DRUG CRAVING [J].

MARKOU, A ;

WEISS, F ;

GOLD, LH ;

CAINE, SB ;

SCHULTEIS, G ;

KOOB, GF .

PSYCHOPHARMACOLOGY, 1993, 112 (2-3) :163-182

[6] Orphanin FQ is a functional anti-opioid peptide [J].

Mogil, JS ;

Grisel, JE ;

Reinscheid, RK ;

Civelli, O ;

Belknap, JK ;

Grandy, DK .

NEUROSCIENCE, 1996, 75 (02) :333-337

[7] MOTIVATIONAL PROPERTIES OF KAPPA AND MU OPIOID RECEPTOR AGONISTS STUDIED WITH PLACE AND TASTE PREFERENCE CONDITIONING [J].

MUCHA, RF ;

HERZ, A .

PSYCHOPHARMACOLOGY, 1985, 86 (03) :274-280

[8] Intracerebroventricular orphanin FQ nociceptin suppresses dopamine release in the nucleus accumbens of anaesthetized rats [J].

Murphy, NP ;

Ly, HT ;

Maidment, NT .

NEUROSCIENCE, 1996, 75 (01) :1-4

[9]

Olive MF, 1998, J PHARMACOL EXP THER, V285, P1310

[10]

Paxinos G., 1986, RAT BRAIN STEREOTAXI, Vsecond

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