Estimation of tumor control probability model parameters from 3-D dose distributions of non-small cell lung cancer patients

被引：254

作者：

Martel, MK ^{[1
]}

Ten Haken, RK ^{[1
]}

Hazuka, MB ^{[1
]}

Kessler, ML ^{[1
]}

Strawderman, M ^{[1
]}

Turrisi, AT ^{[1
]}

Lawrence, TS ^{[1
]}

Fraass, BA ^{[1
]}

Lichter, AS ^{[1
]}

机构：

[1] Univ Michigan, Med Ctr, Dept Radiat Oncol, Ann Arbor, MI 48109 USA

来源：

LUNG CANCER | 1999年 / 24卷 / 01期

关键词：

dose-volume histogram; local control; non-small cell lung cancer; three-dimensional treatment planning; tumor control probability;

D O I：

10.1016/S0169-5002(99)00019-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tumor control probability (TCP) model calculations may be used in a relative manner to evaluate and optimize three-dimensional (3-D) treatment plans. Using a mathematical model which makes a number of simplistic assumptions, TCPs can be estimated from a 3-D dose distribution of the tumor given the dose required for a 50% probability of tumor control (D-50) and the normalized slope (gamma) of the sigmoid-shaped dose-response curve at D-50 The purpose of this work was to derive D-50 and gamma from our clinical experience using 3-D treatment planning to treat non-small cell lung cancer (NSCLC) patients. Our results suggest that for NSCLC patients, the dose to achieve significant probability of tumor control may be large (on the order of 84 Gy) for longer (> 30 months) local progression-free survival. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：31 / 37

页数：7

共 21 条

[1] DOSIMETRIC PRECISION REQUIREMENTS IN RADIATION-THERAPY [J].

BRAHME, A .

ACTA RADIOLOGICA ONCOLOGY, 1984, 23 (05) :379-391

[2] LOCAL-CONTROL IN MEDICALLY INOPERABLE LUNG-CANCER - AN ANALYSIS OF ITS IMPORTANCE IN OUTCOME AND FACTORS DETERMINING THE PROBABILITY OF TUMOR-ERADICATION [J].

DOSORETZ, DE ;

GALMARINI, D ;

RUBENSTEIN, JH ;

KATIN, MJ ;

BLITZER, PH ;

SALENIUS, SA ;

DOSANI, RA ;

RASHID, M ;

MESTAS, G ;

HANNAN, SE ;

CHADHA, TT ;

BHAT, SB ;

SIEGEL, AD ;

CHANDRAHASA, T ;

METKE, MP .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1993, 27 (03) :507-516

[3] AN APPROACH TO THE INTERPRETATION OF CLINICAL-DATA ON THE TUMOR-CONTROL PROBABILITY-DOSE RELATIONSHIP [J].

DUTREIX, J ;

TUBIANA, M ;

DUTREIX, A .

RADIOTHERAPY AND ONCOLOGY, 1988, 11 (03) :239-248

[4]

Fraass BA, 1987, USE COMPUTERS RAD TH, P273

[5] IMPROVED METHODOLOGY FOR ANALYZING LOCAL AND DISTANT RECURRENCE [J].

GELMAN, R ;

GELBER, R ;

HENDERSON, IC ;

COLEMAN, CN ;

HARRIS, JR .

JOURNAL OF CLINICAL ONCOLOGY, 1990, 8 (03) :548-555

[6]

GOITEIN M, 1987, EVALUATION TREATMENT, P1

[7]

Hall E.J, 1988, RADIOBIOLOGY RADIOLO

[8] RESULTS OF HIGH-DOSE THORACIC IRRADIATION INCORPORATING BEAMS EYE VIEW DISPLAY IN NONSMALL CELL LUNG-CANCER - A RETROSPECTIVE MULTIVARIATE-ANALYSIS [J].

HAZUKA, MB ;

TURRISI, AT ;

LUTZ, ST ;

MARTEL, MK ;

TENHAKEN, RK ;

STRAWDERMAN, M ;

BOREMA, PL ;

LICHTER, AS .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1993, 27 (02) :273-284

[9]

HAZUKA MB, 1994, LUNG CANCER S1, V11, P137

[10] NONPARAMETRIC-ESTIMATION FROM INCOMPLETE OBSERVATIONS [J].

KAPLAN, EL ;

MEIER, P .

JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION, 1958, 53 (282) :457-481

← 1 2 3 →