To be or not to be ridded? That is the question addressed by the associative antigen recognition model

The reasons that germline-encoded recognitive sites cannot sort the immune system's large and random somatically generated repertoire into anti-Not-to-be-ridded ('self') and anti-To-be-ridded ('nonself') specificities are analysed. The immune system cannot use 'nonself'-markers of To-be-ridded antigens, pathogenicity, localization, etc.) to sort the repertoire; it may, however, use ('Danger', toll receptors. them to determine the magnitude and class of the effector response.