Different aminoglycoside-resistant phenotypes in a rabbit Staphylococcus aureus endocarditis infection model

被引：12

作者：

Asseray, N

Caillon, J

Roux, N

Jacqueline, C

Bismuth, R

Kergueris, MF

Potel, G

Bugnon, D

机构：

[1] UER Med, Lab Antibiol, Nantes, France

[2] UER Med, Toxicol Lab, Nantes, France

[3] Grp Hosp Pitie Salpetriere, Serv Bacteriol, F-75634 Paris, France

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2002年 / 46卷 / 05期

关键词：

D O I：

10.1128/AAC.46.5.1591-1593.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The impact of different types of enzymatic resistance on the in vivo antibacterial activity of aminoglycosides (amikacin, gentamicin, and netilmicin) was studied in the rabbit endocarditis model with four strains of Staphylococcus aureus. Animals were treated in a manner simulating the administration of a single daily human dose. Amikacin had no effect on the three kanamycin-resistant strains despite apparent susceptibility in the disk diffusion test. Gentamicin appears to be the preferable aminoglycoside for treatment of staphylococcal infections.

引用

页码：1591 / 1593

页数：3

共 21 条

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[2]

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