Emerging role of epigenetics and miRNA in diabetic cardiomyopathy

被引：72

作者：

Asrih, Mohamed ^{[1
]}

Steffens, Sabine ^{[1
]}

机构：

[1] Univ Geneva, Fdn Med Res, Sch Med, Div Cardiol, CH-1211 Geneva 4, Switzerland

来源：

CARDIOVASCULAR PATHOLOGY | 2013年 / 22卷 / 02期

基金：

瑞士国家科学基金会;

关键词：

Diabetes; Epigenetics; Cardiomyopathy; LEFT-VENTRICULAR MASS; HEART-FAILURE; INSULIN-RESISTANCE; GENE-EXPRESSION; SMALL RNAS; MICRORNA; HISTONE; MECHANISMS; MELLITUS; MUSCLE;

D O I：

10.1016/j.carpath.2012.07.004

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

The prevalence of heart failure independent of coronary artery disease and hypertension is increasing rapidly in diabetic patients. Thus, this pathophysiology has been recognized as a distinct clinical entity termed "diabetic cardiomyopathy." Several studies support the notion that diabetes is a threatening insult for the myocardium resulting in functional, cellular, and structural changes manifesting as a cardiac myopathy. Recent data suggested that epigenetics including DNA and histone modifications as well as microRNAs play an important role in the development of cardiac diseases. The role of epigenetics in diabetes is largely recognized; however, its role in diabetes-associated cardiomyopathy remains elusive. Thus, molecular, cellular, and functional modulations in the diabetic cardiomyopathy will be investigated in this review. Moreover, particular attention will be drawn on the epigenetic mechanisms that may play an important role in the pathophysiology of diabetic cardiomyopathy. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：117 / 125

页数：9

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