Controlling HIV pathogenesis: The role of the noncytotoxic anti-HIV response of CD8(+) T cells

被引：404

作者：

Levy, JA ^{[1
]}

Mackewicz, CE ^{[1
]}

Barker, E ^{[1
]}

机构：

[1] UNIV CALIF SAN FRANCISCO,DEPT MED,SAN FRANCISCO,CA 94143

来源：

IMMUNOLOGY TODAY | 1996年 / 17卷 / 05期

关键词：

D O I：

10.1016/0167-5699(96)10011-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Noncytotoxic CD8(+) T cells may play a critical role in preventing progression to disease following human immunodeficiency virus (HIV) infection. This antiviral response, mediated by a novel CD8(+) T-ceII antiviral factor (CAF), occurs soon after infection and is maintained in asymptomatic individuals. Here, Jay Levy and colleagues propose that this antiviral activity represents a natural cellular immune reaction that controls HIV production and protects the host from potential harmful effects of cytotoxic T lymphocytes.

引用

页码：217 / 224

页数：8

共 81 条

[1] AUTRAN B, 1988, AIDS, V2, P179
[2] THE ROLE OF CD8-POSITIVE LYMPHOCYTES IN THE CONTROL OF HIV-1 INFECTION OF PERIPHERAL-BLOOD MONONUCLEAR-CELLS
BAGASRA, O
POMERANTZ, RJ
[J]. IMMUNOLOGY LETTERS, 1993, 35 (02) : 83 - 92
[3] BALER M, 1995, NATURE, V378, P563
[4] EFFECTS OF T(H)1 AND T(H)2 CYTOKINES ON CD8(+) CELL RESPONSE AGAINST HUMAN-IMMUNODEFICIENCY-VIRUS - IMPLICATIONS FOR LONG-TERM SURVIVAL
BARKER, E
MACKEWICZ, CE
LEVY, JA
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (24) : 11135 - 11139
[5] UNLOCKING THE SECRETS OF CTL AND NK CELLS
BERKE, G
[J]. IMMUNOLOGY TODAY, 1995, 16 (07): : 343 - 346
[6] WHY CANT CYTOTOXIC T-CELLS HANDLE HIV
BEVAN, MJ
BRACIALE, TJ
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (13) : 5765 - 5767
[7] VIRUS-SPECIFIC CD8+ CYTOTOXIC T-LYMPHOCYTE ACTIVITY ASSOCIATED WITH CONTROL OF VIREMIA IN PRIMARY HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 INFECTION
BORROW, P
LEWICKI, H
HAHN, BH
SHAW, GM
OLDSTONE, MBA
[J]. JOURNAL OF VIROLOGY, 1994, 68 (09) : 6103 - 6110
[8] BRINCHMANN JE, 1990, J IMMUNOL, V144, P2961
[9] FREQUENCY OF PROVIRUS-BEARING CD4(+) CELLS IN HIV TYPE-1 INFECTION CORRELATES WITH EXTENT OF IN-VITRO APOPTOSIS OF CD8(+) BUT NOT OF CD4(+) CELLS
CARBONARI, M
CIBATI, M
PESCE, AM
SBARIGIA, D
GROSSI, P
DOFFIZI, G
LUZI, G
FIORILLI, M
[J]. AIDS RESEARCH AND HUMAN RETROVIRUSES, 1995, 11 (07) : 789 - 794
[10] QUANTITATIVE-ANALYSIS OF THE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 (HIV-1)-SPECIFIC CYTOTOXIC LYMPHOCYTE-T (CTL) RESPONSE AT DIFFERENT STAGES OF HIV-1 INFECTION - DIFFERENTIAL CTL RESPONSES TO HIV-1 AND EPSTEIN-BARR-VIRUS IN LATE DISEASE
CARMICHAEL, A
JIN, X
SISSONS, P
BORYSIEWICZ, L
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 177 (02) : 249 - 256

← 1 2 3 4 5 6 7 8 9 →