CANCER Novel target to enhance radioiodine uptake in thyroid cancer

被引：7

作者：

Brent, Gregory A. ^{[1
]}

Kogai, Takahiko ^{[2
]}

机构：

[1] Vet Affairs Greater Los Angeles Healthcare Syst, Dept Med, Los Angeles, CA 90073 USA

[2] Dokkyo Med Univ, Dept Infect Control & Clin Lab Med, Mibu, Tochigi 3210293, Japan

来源：

NATURE REVIEWS ENDOCRINOLOGY | 2013年 / 9卷 / 09期

关键词：

SODIUM/IODIDE SYMPORTER EXPRESSION; TUMOR TRANSFORMING GENE;

D O I：

10.1038/nrendo.2013.132

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

The sodium-iodide symporter mediates iodide uptake, but its activity is reduced by the overexpression of pituitary tumour-transforming gene 1 protein-binding factor (PBF) in thyroid tumours. A recent study shows that inhibiting PBF phosphorylation enhances radioiodine uptake in thyroid cancer models.

引用

页码：508 / 509

页数：3

共 10 条

[1]

Small-molecule MAPK inhibitors restore radioiodine incorporation in mouse thyroid cancers with conditional BRAF activation [J].

Chakravarty, Debyani ;

Santos, Elmer ;

Ryder, Mabel ;

Knauf, Jeffrey A. ;

Liao, Xiao-Hui ;

West, Brian L. ;

Bollag, Gideon ;

Kolesnick, Richard ;

Thin, Tin Htwe ;

Rosen, Neal ;

Zanzonico, Pat ;

Larson, Steven M. ;

Refetoff, Samuel ;

Ghossein, Ronald ;

Fagin, James A. .

JOURNAL OF CLINICAL INVESTIGATION, 2011, 121 (12) :4700-4711

[2]

Selumetinib-Enhanced Radioiodine Uptake in Advanced Thyroid Cancer [J].

Ho, Alan L. ;

Grewal, Ravinder K. ;

Leboeuf, Rebecca ;

Sherman, Eric J. ;

Pfister, David G. ;

Deandreis, Desiree ;

Pentlow, Keith S. ;

Zanzonico, Pat B. ;

Haque, Sofia ;

Gavane, Somali ;

Ghossein, Ronald A. ;

Ricarte-Filho, Julio C. ;

Dominguez, Jose M. ;

Shen, Ronglai ;

Tuttle, R. Michael ;

Larson, Steve M. ;

Fagin, James A. .

NEW ENGLAND JOURNAL OF MEDICINE, 2013, 368 (07) :623-632

[3]

Enhancement of sodium/iodide symporter expression in thyroid and breast cancer [J].

Kogai, T. ;

Taki, K. ;

Brent, G. A. .

[4]

Kogai T, 2008, J ENDOCRINOL, V199, P500, DOI [10.1677/JOE-08-0333, 10.1677/JOE-08-0333e]

[5]

The sodium iodide symporter (NIS): Regulation and approaches to targeting for cancer therapeutics [J].

Kogai, Takahiko ;

Brent, Gregory A. .

PHARMACOLOGY & THERAPEUTICS, 2012, 135 (03) :355-370

[6]

The pituitary tumor transforming gene in thyroid cancer [J].

Lewy, G. D. ;

Sharma, N. ;

Seed, R. I. ;

Smith, V. E. ;

Boelaert, K. ;

McCabe, C. J. .

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 2012, 35 (04) :425-433

[7]

Proto-oncogene PBF/PTTG1IP Regulates Thyroid Cell Growth and Represses Radioiodide Treatment [J].

Read, Martin L. ;

Lewy, Greg D. ;

Fong, Jim C. W. ;

Sharma, Neil ;

Seed, Robert I. ;

Smith, Vicki E. ;

Gentilin, Erica ;

Warfield, Adrian ;

Eggo, Margaret C. ;

Knauf, Jeffrey A. ;

Leadbeater, Wendy E. ;

Watkinson, John C. ;

Franklyn, Jayne A. ;

Boelaert, Kristien ;

McCabe, Christopher J. .

CANCER RESEARCH, 2011, 71 (19) :6153-6164

[8]

Smith V. E., J CLIN ENDOCRINOL ME

[9]

A novel mechanism of sodium iodide symporter repression in differentiated thyroid cancer [J].

Smith, Vicki E. ;

Read, Martin L. ;

Turnell, Andrew S. ;

Watkins, Rachel J. ;

Watkinson, John C. ;

Lewy, Greg D. ;

Fong, Jim C. W. ;

James, Sally R. ;

Eggo, Margaret C. ;

Boelaert, Kristien ;

Franklyn, Jayne A. ;

McCabe, Christopher J. .

JOURNAL OF CELL SCIENCE, 2009, 122 (18) :3393-3402

[10]

Pituitary Tumor Transforming Gene Binding Factor: A New Gene in Breast Cancer [J].

Watkins, Rachel J. ;

Read, Martin L. ;

Smith, Vicki E. ;

Sharma, Neil ;

Reynolds, Gary M. ;

Buckley, Laura ;

Doig, Craig ;

Campbell, Moray J. ;

Lewy, Greg ;

Eggo, Margaret C. ;

Loubiere, Laurence S. ;

Franklyn, Jayne A. ;

Boelaert, Kristien ;

McCabe, Christopher J. .

CANCER RESEARCH, 2010, 70 (09) :3739-3749

← 1 →