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Functionalised pyrrolidinones derived from (S)-pyroglutamic acid by cycloaddition reactions

被引：36
作者：
Bailey, JH
Cherry, DT
Crapnell, KM
Moloney, MG
Shim, SB
Bamford, MJ
Lamont, RB
机构：
[1] UNIV OXFORD,DYSON PERRINS LAB,OXFORD OX1 3QY,ENGLAND
[2] GLAXO WELLCOME RES & DEV LTD,MED RES CTR,STEVENAGE SG1 2NY,HERTS,ENGLAND
来源：
TETRAHEDRON | 1997年 / 53卷 / 34期
基金：
英国工程与自然科学研究理事会;
关键词：
D O I：
10.1016/S0040-4020(97)00740-0
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The alpha,beta-unsaturated bicyclic lactams 3a,c, prepared from (S)-pyroglutamic acid, are useful substrates for cycloaddition reactions, giving excellent regio-and diastereocontrol; however, lactam 3c has very superior reactivity with several dienes and dipoles under mild reaction conditions. (C) 1997 Elsevier Science Ltd.
引用
收藏
页码：11731 / 11744
页数：14
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