Amyloidogenic processing of β-amyloid precursor protein in intracellular compartments

被引：155

作者：

Vetrivel, KS ^{[1
]}

Thinakaran, G ^{[1
]}

机构：

[1] Univ Chicago, Dept Neurobiol Pharmacol & Physiol, Chicago, IL 60637 USA

来源：

NEUROLOGY | 2006年 / 66卷

关键词：

D O I：

10.1212/01.wnl.0000192107.17175.39

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Trafficking and proteolytic processing of amyloid precursor protein (APP) have been the focus of numerous investigations in the past two decades, since the identification of A beta as the principal component of brain senile plaques and the cloning of APP cDNA. Tremendous progress has been made in the recent past toward the characterization of beta-and gamma-secretases. Here, we review the salient features of Alzheimer disease amyloidogenesis, and discuss the current knowledge on APP trafficking and amyloidogenic processing of APP in intracellular membrane compartments and microdomains.

引用

页码：S69 / S73

页数：5

共 39 条

[1] Neuronal membrane cholesterol loss enhances amyloid pepticle generation [J].

Abad-Rodriguez, J ;

Ledesma, MD ;

Craessaerts, K ;

Perga, S ;

Medina, M ;

Delacourte, A ;

Dingwall, C ;

De Strooper, B ;

Dotti, CG .

JOURNAL OF CELL BIOLOGY, 2004, 167 (05) :953-960

[2] ADAMs family members as amyloid precursor protein α-secretases [J].

Allinson, TMJ ;

Parkin, ET ;

Turner, AJ ;

Hooper, NM .

JOURNAL OF NEUROSCIENCE RESEARCH, 2003, 74 (03) :342-352

[3] Proposed pathogenetic cascade of inclusion-body myositis:: importance of amyloid-β, misfolded proteins, predisposing genes, and aging [J].

Askanas, V ;

Engel, WK .

CURRENT OPINION IN RHEUMATOLOGY, 2003, 15 (06) :737-744

[4] Inclusion-body myositis and myopathies: different etiologies, possibly similar pathogenic mechanisms [J].

Askanas, V ;

Engel, WK .

CURRENT OPINION IN NEUROLOGY, 2002, 15 (05) :525-531

[5] Functions of lipid rafts in biological membranes [J].

Brown, DA ;

London, E .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 1998, 14 :111-136

[6]

CHECLER F, 1995, J NEUROCHEM, V65, P1431

[7] γ-secretase exists on the plasma membrane as an intact complex that accepts substrates and effects intramembrane cleavage [J].

Chyung, JH ;

Raper, DM ;

Selkoe, DJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (06) :4383-4392

[8] Alzheimer's A beta(1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells [J].

Cook, DG ;

Forman, MS ;

Sung, JC ;

Leight, S ;

Kolson, DL ;

Iwatsubo, T ;

Lee, VMY ;

Doms, RW .

NATURE MEDICINE, 1997, 3 (09) :1021-1023

[9] Exclusively targeting β-secretase to lipid rafts by GPI-anchor addition up-regulates β-site processing of the amyloid precursor protein [J].

Cordy, JM ;

Hussain, I ;

Dingwall, C ;

Hooper, NM ;

Turner, AJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (20) :11735-11740

[10] Amyloidogenic processing of the Alzheimer β-amyloid precursor protein depends on lipid rafts [J].

Ehehalt, R ;

Keller, P ;

Haass, C ;

Thiele, C ;

Simons, K .

JOURNAL OF CELL BIOLOGY, 2003, 160 (01) :113-123

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