Febrile seizures in the developing brain result in persistent modification of neuronal excitability in limbic circuits

被引:234
作者
Chen, K
Baram, TZ
Soltesz, I [1 ]
机构
[1] Univ Calif Irvine, Dept Anat & Neurobiol, Irvine, CA 92697 USA
[2] Univ Calif Irvine, Dept Pediat, Irvine, CA 92697 USA
关键词
D O I
10.1038/11330
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Febrile (fever-induced) seizures affect 3-5% of infants and young children. Despite the high incidence of febrile seizures, their contribution to the development of epilepsy later in life has remained controversial. Combining a new rat model of complex febrile seizures and patch clamp techniques, we determined that hyperthermia-induced seizures in the immature rat cause a selective presynaptic increase in inhibitory synaptic transmission in the hippocampus that lasts into adulthood. The long-lasting nature of these potent alterations in synaptic communication after febrile seizures does not support the prevalent view of the 'benign' nature of early-life febrile convulsions.
引用
收藏
页码:888 / 894
页数:7
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