Nevus density and melanoma risk in women: A pooled analysis to test the divergent pathway hypothesis

被引：60

作者：

Olsen, Catherine M. ^{[1
,2
]}

Zens, Michael S. ^{[3
]}

Stukel, Therese A. ^{[3
,4
]}

Sacerdote, Carlotta ^{[5
,6
]}

Chang, Yu-Mei ^{[7
]}

Armstrong, Bruce K. ^{[8
]}

Bataille, Veronique ^{[9
]}

Berwick, Marianne ^{[10
]}

Elwood, J. Mark ^{[11
]}

Holly, Elizabeth A. ^{[12
]}

Kirkpatrick, Connie ^{[13
]}

Mack, Thomas ^{[14
]}

Bishop, Julia Newton ^{[7
]}

Osterlind, Anne

Swerdlow, Anthony J. ^{[15
]}

Zanetti, Roberto ^{[16
]}

Green, Adele C. ^{[1
]}

Karagas, Margaret R. ^{[3
]}

Whiteman, David C. ^{[1
]}

机构：

[1] Queensland Inst Med Res, Canc & Populat Studies Grp, Brisbane, Qld 4006, Australia

[2] Univ Queensland, Sch Populat Hlth, Brisbane, Qld, Australia

[3] Dartmouth Coll, Hitchcock Med Ctr, Dartmouth Med Sch, Dept Community & Family Med,Sect Biostat & Epidem, Hanover, NH 03756 USA

[4] Inst Clin Evaluat Sci, Toronto, ON, Canada

[5] Univ Turin, Canc Epidemiol Unit, Turin, Italy

[6] Ctr Canc Prevent, CPO, Turin, Italy

[7] Univ Leeds, St James Hosp, Epidemiol & Biostat Sect, Leeds Inst Mol Med,Canc Res UK Clin Ctr Leeds, Leeds LS9 7TF, W Yorkshire, England

[8] Univ Sydney, Sch Publ Hlth, Sydney, NSW 2006, Australia

[9] Kings Coll London, Twin Res & Genet Epidemiol Unit, London WC2R 2LS, England

[10] Univ New Mexico, Dept Internal Med, Albuquerque, NM 87131 USA

[11] BC Canc Agcy, Vancouver, BC, Canada

[12] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA

[13] Franciscan Hlth Syst, Tacoma, WA USA

[14] Univ So Calif, Kenneth Norris Jr Comprehens Canc Ctr, Los Angeles, CA 90033 USA

[15] Inst Canc Res, Epidemiol Sect, Sutton, Surrey, England

[16] Ctr Canc Prevent, CPO, Piedmont Canc Registry, Turin, Italy

来源：

INTERNATIONAL JOURNAL OF CANCER | 2009年 / 124卷 / 04期

基金：

英国医学研究理事会;

关键词：

melanoma; nevus; CUTANEOUS MALIGNANT-MELANOMA; ORAL-CONTRACEPTIVE USE; SITE-SPECIFIC RISK; MELANOCYTIC NEVI; SUN EXPOSURE; NEW-ZEALAND; MELANOCORTIN-1; RECEPTOR; REPRODUCTIVE FACTORS; ANATOMICAL SITE; SOLAR KERATOSES;

D O I：

10.1002/ijc.24011

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A "divergent pathway" model for the development of cutaneous melanoma has been proposed. The model hypothesizes that melanomas occurring in people with a low tendency to develop nevi will, on average, arise more commonly on habitually sun-exposed body sites such as the head and neck. In contrast, people with an inherent propensity to develop nevi will tend to develop melanomas most often on body sites with large melanocyte populations, such as on the back. We conducted a collaborative analysis to test this hypothesis using the original data from 10 case-control studies of melanoma in women (2,406 cases and 3.119 controls). with assessment of the potential confounding effects of socioeconomic, pigmentary and sun exposure-related factors. Higher nevus count on the arm was associated specifically with an increased risk Of melanoma of the trunk (p for trend = 0.0004) and limbs (both tipper and lower limb p for trends = 0.01). but not of the head and neck (p for trend = 0.25). The pooled odds ratios for the highest quartile of nonzero nevus count versus none were 4.6 (95% confidence interval (CI) 2.7-7.6) for melanoma of the trunk 2.0 (95% CI 0.9-4.5) for the head and neck, 4.2 (95% CI 2.3-7.5) for the tipper limbs and 3.4 (95% Cl 1.5-7.9) for (he lower limbs. Aggregate data from these studies suggest that high nevus counts are strongly associated with melanoma of the trunk but less so if at all of the head and neck. This finding supports different etiologic pathways of melanoma development by anatomic site. (c) 2008 Wiley-Liss. Inc.

引用

页码：937 / 944

页数：8

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