Effect of aqueous extract of Commiphora opobalsamum on blood pressure and heart rate in rats

被引：33

作者：

AbdulGhani, AS

Amin, R

机构：

[1] Biology and Biochemistry Department, Faculty of Science, Birzeit University, Birzeit, West Bank

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 1997年 / 57卷 / 03期

关键词：

Commiphora opobalsamum; blood pressure; heart rate; cholinergic receptors; atropine;

D O I：

10.1016/S0378-8741(97)00063-9

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The cardiovascular effects of aqueous extracts from the branches of Commiphora opobalsamum tree were investigated. The intravenous administration of 4 mg/kg of the aqueous extract depressed systemic arterial blood pressure by 20% (P < 0.01) and reduced heart rate of anaesthetised rats by 14% (P < 0.05). The hypotensive and the bradycardiac effects were immediate and in a dose related manner. The hypotensive effect of C. opobalsamum was inhibited by the pretreatment with atropine sulfate (1-4 mg/kg). These results suggest that the hypotensive effect of C. opobalsamum is due to the activation of muscarinic cholinergic receptors. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：219 / 222

页数：4

共 13 条

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[2]

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[3]

ARORA RB, 1972, INDIAN J MED RES, V60, P929

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