Can placental growth factor in maternal circulation identify fetuses with placental intrauterine growth restriction?

被引：93

作者：

Benton, Samantha J. ^{[1
,2
]}

Hu, Yuxiang ^{[1
,2
]}

Xie, Fang ^{[1
]}

Kupfer, Kenneth ^{[4
]}

Lee, Seok-Won ^{[4
]}

Magee, Laura A. ^{[2
,3
]}

von Dadelszen, Peter ^{[1
,2
]}

机构：

[1] Univ British Columbia, Fac Med, Dept Obstet & Gynaecol, Vancouver, BC, Canada

[2] Univ British Columbia, Fac Med, Family Res Inst, Vancouver, BC, Canada

[3] Univ British Columbia, Fac Med, Dept Med, Vancouver, BC, Canada

[4] Alere San Diego Inc, San Diego, CA USA

来源：

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 2012年 / 206卷 / 02期

基金：

加拿大健康研究院;

关键词：

angiogenesis; constitutionally small fetus; diagnostic test; placental growth factor; placental IUGR; LATE-ONSET PREECLAMPSIA; UTERINE ARTERY DOPPLER; SOLUBLE ENDOGLIN; ANGIOGENIC FACTORS; NORMAL-PREGNANCY; EXPRESSION; PRETERM; RISK;

D O I：

10.1016/j.ajog.2011.09.019

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

OBJECTIVE: We investigated whether decreased concentrations of placental growth factor (PlGF) in maternal circulation differentiated placental intrauterine growth restriction (IUGR) from constitutionally small fetuses. Excluding congenital syndromes, infection, and aneuploidy, we assumed IUGR with an abnormal placental pathology to be of placental origin. STUDY DESIGN: The study design included a single site, case-control study of 16 cases (9 placental IUGR, 7 constitutionally small) and 79 normal controls with singleton pregnancies. Plasma PlGF was measured by Triage PlGF immunoassay according to the product insert. A positive PlGF test was defined as a concentration less than the fifth percentile for gestational age for normal pregnancy. RESULTS: A positive PlGF test was found in 9 of 9 placental IUGR cases, 1 of 7 constitutionally small fetuses, and 4 of 79 controls (P < .0001). PlGF identified placental IUGR from constitutionally small fetuses with 100% sensitivity and 86% specificity (P = .0009). CONCLUSION: These preliminary data suggest PlGF may identify placental IUGR antenatally.

引用

页数：7

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