INHIBITORS OF TRANSLATION TARGETING EUKARYOTIC TRANSLATION INITIATION FACTOR 4A

被引：22

作者：

Cencic, Regina ^{[1
]}

Galicia-Vazquez, Gabriela ^{[1
]}

Pelletier, Jerry ^{[1
,2
]}

机构：

[1] McGill Univ, Dept Biochem, Montreal, PQ, Canada

[2] McGill Univ, Rosalind & Morris Goodman Canc Res Ctr, Montreal, PQ, Canada

来源：

RNA HELICASES | 2012年 / 511卷

基金：

加拿大健康研究院;

关键词：

DENDRITIC BC1 RNA; PROTEIN-KINASE-C; WEST-NILE VIRUS; NONSENSE-MEDIATED DECAY; EXPANDED FAT NUCLEOSIDE; ASCITES-TUMOUR CELLS; MESSENGER-RNA; MAMMALIAN TRANSLATION; HELICASE ACTIVITY; FACTOR EIF-4A;

D O I：

10.1016/B978-0-12-396546-2.00020-6

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The RNA helicases eIF4AI and eIF4AII play key roles in recruiting ribosomes to mRNA templates during eukaryotic translation initiation. Small molecule inhibitors of eIF4AI and eIF4AII have been useful for chemically dissecting their role in translation in vitro and in vivo. Here, we describe a screen performed on a small focused library of kinase inhibitors to identify a novel helicase inhibitor. We describe assays that have been critical for characterizing novel RNA helicase inhibitors.

引用

页码：437 / 461

页数：25

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