Evidence for gradients of gene expression correlating with zonal topography of the olfactory sensory map

被引：91

作者：

Norlin, EM ^{[1
]}

Alenius, M ^{[1
]}

Gussing, F ^{[1
]}

Hägglund, M ^{[1
]}

Vedin, V ^{[1
]}

Bohm, S ^{[1
]}

机构：

[1] Umea Univ, Dept Mol Biol, S-90187 Umea, Sweden

来源：

MOLECULAR AND CELLULAR NEUROSCIENCE | 2001年 / 18卷 / 03期

关键词：

D O I：

10.1006/mcne.2001.1019

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Signals regulating diversification of olfactory sensory neurons to express odorant receptors and other genes necessary for correct assembly of the olfactory sensory map persist in the olfactory epithelium of adult mouse. We have screened for genes with an expression pattern correlating with the topography odorant receptor-expression zones. The Msx1 homeobox gene and a semaphorin receptor (Neuropilin-2) showed graded expression patterns in the olfactory epithelium. The gradients of Msx1 and Neuropilin-2 expression in basal cells and neurons, respectively, correlated with expression of a retinoic acid-synthesizing enzyme (RALDH2) in lamina propria. A BMP-type I receptor (Alk6) showed a reverse gradient of expression in the supporting cells of the epithelium. Considering known functions of identified genes in cell specification and axon guidance this suggests that zonal division of the olfactory sensory map is maintained, during continious neurogenesis, as a consequence of topographic counter gradients of positional information.

引用

页码：283 / 295

页数：13

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