Selective urokinase-type plasminogen activator (uPA) inhibitors. Part 2: (3-Substituted-5-halo-2-pyridinyl)guanidines

被引：18

作者：

Barber, CG ^{[1
]}

Dickinson, RP ^{[1
]}

机构：

[1] Pfizer Ltd, Global Res & Dev, Dept Discovery Chem, Sandwich CT13 9NJ, Kent, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 02期

关键词：

D O I：

10.1016/S0960-894X(01)00702-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Based on previous modeling predictions, a series of (3-substituted-5-chloro-2-pyridinyl)guanidines have been designed with good potency and selectivity for urokinase-type plasminogen activator (uPA). Compound 3 has a K-i of 0.17 muM and greater than 300-fold selectivity with respect to tPA and plasmin (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：185 / 187

页数：3

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