Smoking and therapeutic response to clozapine in patients with schizophrenia

被引:134
作者
McEvoy, JP
Freudenreich, O
Wilson, WH
机构
[1] Duke Univ, Med Ctr, Durham, NC USA
[2] Robert Wood Johnson Med Ctr, New Brunswick, NJ USA
关键词
nicotine; smoking; clozapine; schizophrenia;
D O I
10.1016/S0006-3223(98)00377-1
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Background: Of patients with schizophrenia, 70 to 80% smoke. Nicotine corrects certain information processing and cognitive psychomotor deficits seen in many patients with schizophrenia. Clozapine, but not conventional antipsychotics, has been shown to correct some of these deficits. Methods: We assessed psychopathology and smoking in 70 patients with treatment refractory schizophrenia (55 smokers and IS nonsmokers) at baseline when they were receiving conventional antipsychotics and again after they were switched to clozapine. Results: Smokers showed significantly greater therapeutic response to clozapine than nonsmokers. Smokers smoked less when treated with clozapine than when treated with conventional antipsychotics. Conclusions: Certain patients with schizophrenia have contributing pathophysiologic mechanisms that respond favorably to either nicotine or clozapine, (C) 1999 Society of Biological Psychiatry.
引用
收藏
页码:125 / 129
页数:5
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