The commensal microbiota drives immune homeostasis

被引：51

作者：

Arrieta, Marie-Claire ^{[1
]}

Finlay, Barton Brett ^{[1
,2
,3
]}

机构：

[1] Univ British Columbia, Michael Smith Labs, Vancouver, BC V6T 1Z4, Canada

[2] Univ British Columbia, Dept Microbiol & Immunol, Vancouver, BC V6T 1Z4, Canada

[3] Univ British Columbia, Dept Biochem & Mol Biol, Vancouver, BC V6T 1Z4, Canada

来源：

FRONTIERS IN IMMUNOLOGY | 2012年 / 3卷

关键词：

intestinal microbiota; immune homeostasis; SEGMENTED FILAMENTOUS BACTERIA; INTESTINAL MICROBIOTA; LAMINA PROPRIA; GERM-FREE; ESCHERICHIA-COLI; T-CELLS; COLONIZATION; FLORA; MATURATION; DIVERSITY;

D O I：

10.3389/fimmu.2012.00033

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

For millions of years, microbes have coexisted with eukaryotic cells at the mucosal surfaces of vertebrates in a complex, yet usually harmonious symbiosis. An ever-expanding number of reports describe how eliminating or shifting the intestinal microbiota has profound effects on the development and functionality of the mucosal and systemic immune systems. Here, we examine some of the mechanisms by which bacterial signals affect immune homeostasis. Focusing on the strategies that microbes use to keep our immune system healthy, as opposed to trying to correct the immune imbalances caused by dysbiosis, may prove to be a more astute and efficient way of treating immune-mediated disease.

引用

页数：6

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