Multi-valent polymer of vancomycin: enhanced antibacterial activity against VRE

被引：90

作者：

Arimoto, H ^{[1
]}

Nishimura, K

Kinumi, T

Hayakawa, I

Uemura, D

机构：

[1] Shizuoka Univ, Fac Sci, Dept Chem, Ohya, Shizuoka 4228529, Japan

[2] Natl Inst Infect Dis, Dept Biochem & Cell Biol, Tokyo 1628640, Japan

[3] Nagoya Univ, Grad Sch Sci, Dept Chem, Chikusa Ku, Nagoya, Aichi 4648602, Japan

来源：

CHEMICAL COMMUNICATIONS | 1999年 / 15期

关键词：

D O I：

10.1039/a903529j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A multivalent polymer of vancomycin, synthesized via ring-opening metathesis polymerization (ROMP), exhibited significant enhancement of antibacterial activity against vancomycin-resistant enterococi (VRE).

引用

页码：1361 / 1362

页数：2

共 18 条

[1] Chemo-enzymatic transformations in sensitive systems: Lipase mediated hydrolysis of vancomycin esters.
Adamczyk, M
Grote, J
Rege, S
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1998, 8 (08) : 885 - 890
[2] Armstrong SK, 1998, J CHEM SOC PERK T 1, P371
[3] Synthesis of penicillin derived polymers utilising ring-opening metathesis polymerisation methodology
Biagini, SCG
Gibson, VC
Giles, MR
Marshall, EL
North, M
[J]. CHEMICAL COMMUNICATIONS, 1997, (12) : 1097 - 1098
[4] Reductive alkylation of glycopeptide antibiotics: Synthesis and antibacterial activity
Cooper, RDG
Snyder, NJ
Zweifel, MJ
Staszak, MA
Wilkie, SC
Nicas, TI
Mullen, DL
Butler, TF
Rodriguez, MJ
Huff, BE
Thompson, RC
[J]. JOURNAL OF ANTIBIOTICS, 1996, 49 (06) : 575 - 581
[5] Thymine functionalised polymers via living ring-opening metathesis polymerisation
Gibson, VC
Marshall, EL
North, M
Robson, DA
Williams, PJ
[J]. CHEMICAL COMMUNICATIONS, 1997, (12) : 1095 - 1096
[6] Recent advances in olefin metathesis and its application in organic synthesis
Grubbs, RH
Chang, S
[J]. TETRAHEDRON, 1998, 54 (18) : 4413 - 4450
[7] VANCOMYCIN - STRUCTURE AND TRANSFORMATION TO CDP-I
HARRIS, CM
KOPECKA, H
HARRIS, TM
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1983, 105 (23) : 6915 - 6922
[8] Strength in numbers: Non-natural polyvalent carbohydrate derivatives
Kiessling, LL
Pohl, NL
[J]. CHEMISTRY & BIOLOGY, 1996, 3 (02): : 71 - 77
[9] Living ring-opening metathesis polymerization in aqueous media catalyzed by well-defined ruthenium carbene complexes
Lynn, DM
Kanaoka, S
Grubbs, RH
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1996, 118 (04) : 784 - 790
[10] Mammen M, 1998, ANGEW CHEM INT EDIT, V37, P2755

← 1 2 →