Plasma vaspin concentrations are decreased in acute coronary syndrome, but unchanged in patients without coronary lesions

被引：41

作者：

Zhang, Baowei ^{[1
,2
]}

Peng, Wenhui ^{[1
]}

Li, Hailing ^{[1
]}

Lu, Yuyan ^{[1
]}

Zhuang, Jianhui ^{[1
]}

Wang, Ke ^{[1
]}

Su, Yang ^{[1
]}

Xu, Yawei ^{[1
]}

机构：

[1] Tongji Univ, Sch Med, Shanghai Peoples Hosp 10, Dept Cardiol, Shanghai 200072, Peoples R China

[2] Jiangsu Univ, Affiliated Peoples Hosp, Dept Med, Dept Cardiol, Zhenjiang, Peoples R China

来源：

CLINICAL BIOCHEMISTRY | 2013年 / 46卷 / 15期

基金：

中国国家自然科学基金;

关键词：

Vaspin; Coronary artery disease; Acute coronary syndrome; Acute myocardial infarction; FREE FATTY-ACID; NF-KAPPA-B; MYOCARDIAL-INFARCTION; ADIPOSE-TISSUE; ASSOCIATION; OBESITY; CELLS; SERUM; ATHEROSCLEROSIS; ADIPOCYTOKINE;

D O I：

10.1016/j.clinbiochem.2013.06.028

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

100118 [医学信息学]; 100208 [临床检验诊断学];

摘要：

Objective: Previous studies suggested that decreased serum vaspin levels were associated with coronary artery disease (CAD). The present study aimed to investigate the association between plasma vaspin levels and different states of CAD. Design and methods: A total of 162 patients with coronary angiography (CAG) proved that CAD was enrolled. Additional 103 patients complained with "chest discomfort" with negative CAG, and 60 normal subjects were enrolled in this study. The levels of plasma vaspin, adiponectin, clinical parameters, lipid profile and C reactive protein (CRP) were measured. Results: The levels of plasma vaspin were significantly lower in the CAD group (0.47 +/- 0.63 mu g/L) than those in the healthy group and CAG (-) group (all p < 0.001). In CAD group, the pos hoc analysis showed that serum vaspin concentration in acute myocardial infarction group (0.21 +/- 0.19 mu g/L) was significantly lower than that in the unstable angina pectoris group (0.40 +/- 0.37 mu g/L) (p = 0.012), and serum vaspin concentration in unstable angina pectoris was significantly lower than that in stable angina pectoris group (0.92 +/- 0.94 mu g/L) (p = 0.013). The plasma vaspin concentration was also negatively correlated with the severity of CAD (1-vessel: 0.86 +/- 0.90 mu g/L; 2-vessel: 0.36 +/- 0.39 mu g/L; 3-vessel: 0.21 +/- 0.16 mu g/L). The plasma vaspin concentration in CAG (-) group with "chest discomfort" (1.93 +/- 2.57 mu g/L) was similar to the healthy control group (2.18 +/- 3.49 mu g/L). Conclusions: The plasma vaspin concentration correlated to the severity of CAD. Furthermore, plasma vaspin has a value of avoiding patients without CAD from unnecessary CAG. (C) 2013 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

引用

页码：1520 / 1525

页数：6

共 27 条

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