Effects of influenza A virus infection on migrating mallard ducks

被引:151
作者
Latorre-Margalef, Neus [1 ]
Gunnarsson, Gunnar [1 ,2 ]
Munster, Vincent J. [3 ]
Fouchier, Ron A. M. [3 ]
Osterhaus, Albert D. M. E. [3 ]
Elmberg, Johan [2 ]
Olsen, Bjorn [1 ,4 ]
Wallensten, Anders [1 ]
Haemig, Paul D. [1 ]
Fransson, Thord [5 ]
Brudin, Lars [1 ,6 ]
Waldenstrom, Jonas [1 ,7 ]
机构
[1] Univ Kalmar, Sch Pure & Appl Nat Sci, Sect Zoonot Ecol & Epidemiol, S-39182 Kalmar, Sweden
[2] Kristianstad Univ, Aquat Biol & Chem Grp, S-29188 Kristianstad, Sweden
[3] Erasmus MC, Dept Virol, NL-3000 CA Rotterdam, Netherlands
[4] Univ Uppsala Hosp, Dept Med Sci, Infect Dis Sect, S-75185 Uppsala, Sweden
[5] Swedish Museum Nat Hist, Bird Ringing Ctr, S-10405 Stockholm, Sweden
[6] Kalmar Cty Hosp, S-38195 Kalmar, Sweden
[7] Lund Univ, Dept Anim Ecol, S-22100 Lund, Sweden
基金
瑞典研究理事会;
关键词
influenza A virus; disease ecology; migration; NORTHERN EUROPE; WILD BIRDS; ECOLOGY; H5N1; PATHOGENICITY; EVOLUTION; ASIA;
D O I
10.1098/rspb.2008.1501
中图分类号
Q [生物科学];
学科分类号
090105 [作物生产系统与生态工程];
摘要
The natural reservoir of influenza A virus is waterfowl, particularly dabbling ducks (genus Anas). Although it has long been assumed that waterfowl are asymptomatic carriers of the virus, a recent study found that low-pathogenic avian influenza (LPAI) infection in Bewick's swans (Cygnus columbianus bewickii) negatively affected stopover time, body mass and feeding behaviour. In the present study, we investigated whether LPAI infection incurred ecological or physiological costs to migratory mallards (Anas platyrhynchos) in terms of body mass loss and staging time, and whether such costs could influence the likelihood for long-distance dispersal of the avian influenza virus by individual ducks. During the autumn migrations of 2002-2007, we collected faecal samples (n = 10 918) and biometric data from mallards captured and banded at Ottenby, a major staging site in a flyway connecting breeding and wintering areas of European waterfowl. Body mass was significantly lower in infected ducks than in uninfected ducks (mean difference almost 20 g over all groups), and the amount of virus shed by infected juveniles was negatively correlated with body mass. There was no general effect of infection on staging time, except for juveniles in September, in which birds that shed fewer viruses stayed shorter than birds that shed more viruses. LPAI infection did not affect speed or distance of subsequent migration. The data from recaptured individuals showed that the maximum duration of infection was on average 8.3 days (s.e. 0.5), with a mean minimum duration of virus shedding of only 3.1 days (s.e. 0.1). Shedding time decreased during the season, suggesting that mallards acquire transient immunity for LPAI infection. In conclusion, deteriorated body mass following infection was detected, but it remains to be seen whether this has more long-term fitness effects. The short virus shedding time suggests that individual mallards are less likely to spread the virus at continental or intercontinental scales.
引用
收藏
页码:1029 / 1036
页数:8
相关论文
共 31 条
[1]
PATHOGENICITY OF 4 AVIAN INFLUENZA-VIRUSES FOR FOWLS, TURKEYS AND DUCKS [J].
ALEXANDER, DJ ;
ALLAN, WH ;
PARSONS, DG ;
PARSONS, G .
RESEARCH IN VETERINARY SCIENCE, 1978, 24 (02) :242-247
[2]
Ecology of spring-migrating Anatidae: a review [J].
Arzel, C ;
Elmberg, J ;
Guillemain, M .
JOURNAL OF ORNITHOLOGY, 2006, 147 (02) :167-184
[3]
Berthold P., 2001, Bird Migration: A General Study
[4]
CAPUA I, 2006, INFLUENZA OTHER RESP, V1, P11, DOI DOI 10.1111/J.1750-2659.2006.00004.X
[5]
PATHOLOGICAL LESIONS IN THE LUNGS OF DUCKS INFECTED WITH INFLUENZA-A VIRUSES [J].
COOLEY, AJ ;
VANCAMPEN, H ;
PHILPOTT, MS ;
EASTERDAY, BC ;
HINSHAW, VS .
VETERINARY PATHOLOGY, 1989, 26 (01) :1-5
[6]
Fransson T., 2001, SWEDISH BIRD RINGING
[7]
Epidemiology -: Reactivation of Borrelia infection in birds [J].
Gylfe, Å ;
Bergström, S ;
Lunström, J ;
Olsen, B .
NATURE, 2000, 403 (6771) :724-725
[8]
THE ECOLOGY OF INFLUENZA-VIRUSES IN DUCKS AND ANALYSIS OF INFLUENZA-VIRUSES WITH MONOCLONAL-ANTIBODIES [J].
HINSHAW, VS ;
WEBSTER, RG ;
BEAN, WJ ;
SRIRAM, G .
COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES, 1980, 3 (1-2) :155-164
[9]
AVIAN INFLUENZA VIRUS INFECTIONS .4. RESPONSE OF PHEASANTS, DUCKS, AND GEESE TO INFLUENZA A/TURKEY/WISCONSIN/1966 VIRUS [J].
HOMME, PJ ;
EASTERDAY, BC .
AVIAN DISEASES, 1970, 14 (02) :285-+
[10]
Role of domestic ducks in the propagation and biological evolution of highly pathogenic H5N1 influenza viruses in Asia [J].
Hulse-Post, DJ ;
Sturm-Ramirez, KM ;
Humberd, J ;
Seiler, P ;
Govorkova, EA ;
Krauss, S ;
Scholtissek, C ;
Puthavathana, P ;
Buranathai, C ;
Nguyen, TD ;
Long, HT ;
Naipospos, TSP ;
Chen, H ;
Ellis, TM ;
Guan, Y ;
Peiris, JSM ;
Webster, RG .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (30) :10682-10687