Anthelmintic activity of flavonoids Isolated from roots of Andira anthelmia (Leguminosae)

被引：15

作者：

da Silva, Virginia C. ^{[1
]}

de Carvalho, Mario G. ^{[1
]}

Borba, Helcio R. ^{[2
]}

Silva, Sandra L. C. ^{[3
]}

机构：

[1] Univ Fed Rural Rio de Janeiro, Inst Ciencias Exatas, BR-23890000 Seropedica, RJ, Brazil

[2] Univ Fed Rural Rio de Janeiro, Inst Biol, Seropedica, RJ, Brazil

[3] Univ Fed Sudoeste Bahia, Dept Estudos Basicos & Instrumentais, BR-45700000 Itapetinga, BA, Brazil

来源：

REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY | 2008年 / 18卷 / 04期

关键词：

Andira anthelmia; flavonoids; anthelmintic activity;

D O I：

10.1590/S0102-695X2008000400013

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Anthelmintic activity of flavonoids Isolated from roots of Andira anthelmia (Leguminosae). Bioactivity-guided fractions of the methanol extract from the roots of Andira anthelmia led the isolation of the isoflavones biochanin A and genistein From the ethyl acetate fraction; biochanin A 7-O-beta-D-glucopyranoside, biochanin A 7-O-alpha-L-rhamnopyranosyl-(1 -> 6)-beta-D-glucopyranoside and biochanin A 7-O-beta-D-apioluranosyl-(1 -> 5)- beta-D-apiofuranosyl-(1 -> 6)-beta-D-glucopyranoside from the n-butanol fraction and catechin from the methanol one. Their structures were elucidated on the basis of spectroscopy data. The anthelmintic activity was investigated in mice naturally infected by Aspiculuris tetraptera. The compounds administered in the animals by intragastric route in doses of 2.0 mg.kg(-1), were effective in the removal of the total number of the A, tetraptera when compared with the control group.

引用

页码：573 / 576

页数：4

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