Biology, structure and mechanism of P-type ATPases

被引：457

作者：

Kühlbrandt, W ^{[1
]}

机构：

[1] Max Planck Inst Biophys, D-60439 Frankfurt, Germany

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2004年 / 5卷 / 04期

关键词：

D O I：

10.1038/nrm1354

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

P-type ATPases are ion pumps that carry out many fundamental processes in biology and medicine, ranging from the generation of membrane potential to muscle contraction and the removal of toxic ions from cells. Making use of the energy stored in ATP, they transport specific ions across the cell membrane against a concentration gradient. Recent X-ray structures and homology models of P-type pumps now provide a basis for understanding the molecular mechanism of ATP-driven ion transport.

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页码：282 / 295

页数：14

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