Synthesis and biological evaluation of flavonoids and related compounds as gastroprotective agents

被引：33

作者：

Ares, JJ

Outt, PE

Randall, JL

Johnston, JN

Murray, PD

OBrien, LM

Weisshaar, PS

Ems, BL

机构：

[1] Procter and Gamble Company, Miami Valley Laboratories, Cincinnati, OH 45253-8707

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 08期

关键词：

D O I：

10.1016/0960-894X(96)00134-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Several analogs of the gastroprotective molecule flavone have been synthesized and evaluated for gastroprotective activity. A C2-C3 double bond and an intact C ring appear necessary for optimum activity. Activity can be retained by replacing the 2-phenyl substituent with other groups but is eliminated when this ring is moved from the 2- to the 3-position. Copyright (C) 1996 Elsevier Science Ltd

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页码：995 / 998

页数：4

相关论文

共 17 条

[1] SYNTHESIS AND BIOLOGICAL EVALUATION OF SUBSTITUTED FLAVONES AS GASTROPROTECTIVE AGENTS [J].

ARES, JJ ;

OUTT, PE ;

RANDALL, JL ;

MURRAY, PD ;

WEISSHAAR, PS ;

OBRIEN, LM ;

EMS, BL ;

KAKODKAR, SV ;

KELM, GR ;

KERSHAW, WC ;

WERCHOWSKI, KM ;

PARKINSON, A .

JOURNAL OF MEDICINAL CHEMISTRY, 1995, 38 (25) :4937-4943

[2] A CONVENIENT LARGE-SCALE SYNTHESIS OF 5-METHOXYFLAVONE AND ITS APPLICATION TO ANALOG PREPARATION [J].

ARES, JJ ;

OUTT, PE ;

KAKODKAR, SV ;

BUSS, RC ;

GEIGER, JC .

JOURNAL OF ORGANIC CHEMISTRY, 1993, 58 (27) :7903-7905

[3] SOME PROPERTIES OF 4-THIONFLAVONE AND ITS METHIODIDE, AND OF 4-THIONCHROMONES [J].

BAKER, W ;

HARBORNE, JB ;

OLLIS, WD .

JOURNAL OF THE CHEMICAL SOCIETY, 1952, (APR) :1303-1309

[4] SYNTHESIS OF HETEROCYCLIC-SUBSTITUTED CHROMONES AND CHALCONES [J].

DEVITT, PF ;

TIMONEY, A ;

VICKARS, MA .

JOURNAL OF ORGANIC CHEMISTRY, 1961, 26 (12) :4941-&

[5] THE CHEMISTRY OF 2'-AMINO ANALOGS OF 2'-HYDROXYCHALCONE AND ITS DERIVATIVES [J].

DONNELLY, JA ;

FARRELL, DF .

JOURNAL OF ORGANIC CHEMISTRY, 1990, 55 (06) :1757-1761

[6]

FEUER L, 1979, Patent No. 4166862

[7] TOWARD AN EPIDEMIOLOGY OF GASTROPATHY ASSOCIATED WITH NONSTEROIDAL ANTIINFLAMMATORY DRUG-USE [J].

FRIES, JF ;

MILLER, SR ;

SPITZ, PW ;

WILLIAMS, CA ;

HUBERT, HB ;

BLOCH, DA .

GASTROENTEROLOGY, 1989, 96 (02) :647-655

[8]

GEIS GS, 1991, J RHEUMATOL, V18, P11

[9]

HIRAO I, 1984, SYNTHESIS-STUTTGART, P1076

[10]

KIUCHI F, 1990, CHEM PHARM BULL, V38, P1862