Adoptive autoimmune hyperthyroidism following allogeneic stem cell transplantation from an HLA-identical sibling with Graves' disease

被引：39

作者：

Berisso, GA

van Lint, MT

Bacigalupo, A

Marmont, AM ^{[1
]}

机构：

[1] S Martinos Hosp, Div Haematol 2, Genoa, Italy

[2] S Martinos Hosp, Stem Cell Transplantat Ctr, Genoa, Italy

来源：

BONE MARROW TRANSPLANTATION | 1999年 / 23卷 / 10期

关键词：

BMT; adoptive autoimmunity; hyperthyroidism;

D O I：

10.1038/sj.bmt.1701760

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Autoimmune diseases which follow allogeneic BMT from a donor who is a patient or a carrier of an autoimmune condition are considered to be a paradigm of adoptive autoimmunity, Seven cases of autoimmune thyroiditis associated with clinical hyperthyroidism have been published to date, In the case reported here a 35-year-old female patient with AML of the M2 subtype received unmanipulated PBSC from her HLA-identical sister who had therapeutically controlled Graves' disease. Antithyroid antibodies, including thyrotropin receptor (TSHR) antibodies, appeared 1 year after transplant. Clinical hyperthyroidism requiring thyrostatic medication appeared after 2 years. The biological and clinical implications of adoptive, post-transplant autoimmunity are briefly discussed.

引用

页码：1091 / 1092

页数：2

共 10 条

[1]

BOITARD C, 1996, B CELLS AUTOANTIBODY

[2] Bone marrow transplantation for autoimmune diseases [J].