A new intronic polymorphism in the C7 gene 36 bp from the common expressed C7 M/N polymorphism

被引：14

作者：

Fernie, BA ^{[1
]}

Wurzner, R ^{[1
]}

Orren, A ^{[1
]}

Hobart, M ^{[1
]}

机构：

[1] UNIV CAMBRIDGE,CTR MRC,MOLEC IMMUNOPATHOL UNIT,CAMBRIDGE CB2 2QH,ENGLAND

来源：

ANNALS OF HUMAN GENETICS | 1996年 / 60卷

关键词：

D O I：

10.1111/j.1469-1809.1996.tb01187.x

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We report a new polymorphism in the complement C7 gene that results from an A-C transversion in intron 12, 27 bp upstream of exon 13 (C712.-27) and 36 bp upstream of the point mutation that underlies the C7 M/N antigenic polymorphism. The C7 12.-27 polymorphism subdivides C7 M haplotypes, but not C7 hi. It also sheds light on the evolution of the various types of deficiency genes at the adjacent CB locus.

引用

页码：179 / 182

页数：4

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