Subversion of Cell Signaling by Pathogens

被引：84

作者：

Alto, Neal M. ^{[1
]}

Orth, Kim ^{[1
]}

机构：

[1] UT SW Med Ctr, Dallas, TX 75390 USA

来源：

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY | 2012年 / 4卷 / 09期

关键词：

ACTIN-FILAMENT NUCLEATION; GTPASE-ACTIVATING PROTEIN; CLASS-I MOLECULES; EFFECTOR PROTEIN; ADP-RIBOSYLATION; RHO-GTPASES; ADENOVIRUS E4ORF6; STRUCTURAL INSIGHTS; KINASE ACTIVATION; SHIGELLA-FLEXNERI;

D O I：

10.1101/cshperspect.a006114

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Pathogens exploit several eukaryotic signaling pathways during an infection. They have evolved specific effectors and toxins to hijack host cell machinery for their own benefit. Signaling molecules are preferentially targeted by pathogens because they globally regulate many cellular processes. Both viruses and bacteria manipulate and control pathways that regulate host cell survival and shape, including MAPK signaling, G-protein signaling, signals controlling cytoskeletal dynamics, and innate immune responses.

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页数：16

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