ABC proteins of Leishmania

被引：46

作者：

Légaré, D

Cayer, S

Singh, AK

Richard, D

Papadopoulou, B

Ouellette, M

机构：

[1] CHU Laval, Ctr Rech, Ctr Rech Infectiol, Quebec City, PQ G1V 4G2, Canada

[2] Univ Laval, Fac Med, Dept Microbiol, Quebec City, PQ G1K 7P4, Canada

来源：

JOURNAL OF BIOENERGETICS AND BIOMEMBRANES | 2001年 / 33卷 / 06期

关键词：

Leishmania; ABC proteins; efflux; drug resistance; glutathione; trypanothione; sequestration;

D O I：

10.1023/A:1012870904097

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

ABC proteins were first characterized in the protozoan parasite Leishmania while studying mechanisms of drug resistance. PGPA is involved in resistance to arsenite and antimonite and it most likely confers resistance by sequestering metal-thiol conjugates into an intracellular vesicle. PGPA is part of gene family with at least four more members which are in search of a function. Leishmania also contains a P-glycoprotein, homologous to the mammalian MDR1, that is involved in multidrug resistance. The ongoing genome project of Leishmania has pinpointed several novel ABC transporters and experiments are carried out to study the function of the ABC proteins in drug resistance and in host-pathogen interactions.

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收藏

页码：469 / 474

页数：6

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